Innate immune control and regulation of influenza virus infections

被引：127

作者：

McGill, Jodi

Heusel, Jonathan W.

Legge, Kevin L. ^{[1
]}

机构：

[1] Univ Iowa, Dept Pathol, Iowa City, IA 52242 USA

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2009年 / 86卷 / 04期

基金：

美国国家卫生研究院;

关键词：

NK cells; macrophages; dendritic cells; CD8(+) T-CELLS; PLASMACYTOID DENDRITIC CELLS; TUMOR-NECROSIS-FACTOR; NATURAL-KILLER-CELLS; RESTRICTED ANTIGEN PRESENTATION; PULMONARY ALVEOLAR MACROPHAGES; STRAND RNA VIRUSES; A VIRUS; LYMPH-NODE; IN-VIVO;

D O I：

10.1189/jlb.0509368

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Adaptive immune responses are critical for the control and clearance of influenza A virus (IAV) infection. However, in recent years, it has become increasingly apparent that innate immune cells, including natural killer cells, alveolar macrophages (aM phi), and dendritic cells ( DC) are essential following IAV infection in the direct control of viral replication or in the induction and regulation of virus-specific adaptive immune responses. This review will discuss the role of these innate immune cells following IAV infection, with a particular focus on DC and their ability to induce and regulate the adaptive IAV-specific immune response. J. Leukoc. Biol. 86: 803-812; 2009.

引用

收藏

页码：803 / 812

页数：10

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