The human ASCL2 gene escaping genomic imprinting and its expression pattern

被引：30

作者：

Miyamoto, T ^{[1
]}

Hasuike, S ^{[1
]}

Jinno, Y ^{[1
]}

Soejima, H ^{[1
]}

Yun, K ^{[1
]}

Miura, K ^{[1
]}

Ishikawa, M ^{[1
]}

Niikawa, N ^{[1
]}

机构：

[1] Nagasaki Univ, Sch Med, Dept Human Genet, Nagasaki 852, Japan

来源：

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS | 2002年 / 19卷 / 05期

关键词：

ASCL2; imprinting; expression; placenta;

D O I：

10.1023/A:1015362903486

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The mouse achaete-scute homolog-2 gene (Ascl2 or Mash2) encodes a transcription factor playing a role in the development of the trophoblast. The Ascl2 is an imprinted gene with maternal expression and assigned to an imprinting gene cluster region (ICR) at a distal region of mouse chromosome 7. We previously isolated a phage clone carrying the human homolog, ASCL2, and mapped it to human chromosome 11p15.5, a human ICR. In the present study, we demonstrate the expression patterns of the human ASCL2 in the fetus at a stage between first and second trimesters and in the placental tissues. In addition, it has been shown that the human ASCL2 gene escapes genomic imprinting.

引用

页码：240 / 244

页数：5

共 15 条

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