Nongenomic androgen activation of phosphatidylinositol 3-kinase/Akt signaling pathway in MC3T3-E1 osteoblasts

被引：81

作者：

Kang, HY

Cho, CL

Huang, KL

Wang, JC

Hu, YC

Lin, HK

Chang, CS

Huang, KE

机构：

[1] Chang Gung Univ, Grad Inst Clin Med Sci, Kaohsiung 866, Taiwan

[2] Chang Gung Univ, Mem Hosp, Ctr Menopause & Reprod Med Res, Kaohsiung 866, Taiwan

[3] Natl Sun Yat Sen Univ, Dept Biol Sci, Kaohsiung 80424, Taiwan

[4] Univ Rochester, Ctr Canc, George Whipple Lab Canc Res, Dept Pathol, Rochester, NY 14627 USA

[5] Univ Rochester, Ctr Canc, George Whipple Lab Canc Res, Dept Urol, Rochester, NY 14627 USA

[6] Univ Rochester, Ctr Canc, George Whipple Lab Canc Res, Dept Radiat Oncol, Rochester, NY 14627 USA

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2004年 / 19卷 / 07期

关键词：

androgens; osteoblasts; molecular pathway; androgen receptor; nongenomic actions;

D O I：

10.1359/JBMR.040306

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Androgens have important effects on the bone metabolism. However, the effect and mechanism of androgen action on the osteoblasts remains unknown. Here we showed that androgens increase phosphorylation and nuclear translocation of Akt. siRNA-AR prevented androgen-induced Akt activation in MC3T3-E1 cells. This suggests that nongenomic androgen activation of Akt is mediated by androgen receptor in osteoblasts.

引用

页码：1181 / 1190

页数：10

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