(P)-helicene displays chiral selection in binding to Z-DNA

被引：207

作者：

Xu, Y

Zhang, YX

Sugiyama, H

Umano, T

Osuga, H

Tanaka, K ^{[1
]}

机构：

[1] Tokyo Med & Dent Univ, Inst Biomat & Bioengn, Chiyoda Ku, Tokyo 1010062, Japan

[2] Kyoto Univ, Grad Sch Sci, Dept Chem, Kyoto, Japan

[3] Wakayama Univ, Fac Syst Engn, Dept Mat Sci & Chem, Wakayama 6408510, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 21期

关键词：

D O I：

10.1021/ja0499748

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Enantiomeric helicenes of (P)-A and (M)-A were synthesized. The binding of the helicenes to B- and Z-DNA was studied quantitatively by CD, equilibrium dialysis, and fluorescence spectroscopy. Enantiomeric (P)-A not only bound selectively to Z-DNA but also effectively converted the B-DNA conformation to Z-DNA. The enantioselectivity of the helicenes offers a new route for the rational design of inhibitors of biological functions that may depend on Z-DNA. Copyright © 2004 American Chemical Society.

引用

页码：6566 / 6567

页数：2

共 18 条

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