GDNF - A potential target to treat addiction

被引：72

作者：

Carnicella, Sebastien ^{[1
]}

Ron, Dorit ^{[1
,2
]}

机构：

[1] Univ Calif San Francisco, Ernest Gallo Res Ctr, Emeryville, CA 94608 USA

[2] Univ Calif San Francisco, Dept Neurol, Emeryville, CA 94608 USA

来源：

PHARMACOLOGY & THERAPEUTICS | 2009年 / 122卷 / 01期

关键词：

GDNF; Growth factor; Addiction; Alcohol; Psychostimulants; Opioids; NEUROTROPHIC-FACTOR GDNF; MIDBRAIN DOPAMINERGIC-NEURONS; RECEPTOR TYROSINE KINASE; MICE LACKING GDNF; IBOGA ALKALOID CONGENER; VENTRAL TEGMENTAL AREA; NECROSIS-FACTOR-ALPHA; RAT PARKINSON MODEL; BLOOD-BRAIN-BARRIER; DIPEPTIDE LEU-ILE;

D O I：

10.1016/j.pharmthera.2008.12.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The glial cell line-derived neurotrophic factor (GDNF) is a secreted protein, best known for its role in the development of the central and peripheral nervous systems and the survival of adult dopaminergic neurons. More recently, accumulating evidence suggests that GDNF plays a unique role in negatively regulating the actions of drugs of abuse. In this article, we review these data and highlight the possibility that the GDNF pathway may be a promising target for the treatment of addiction. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：9 / 18

页数：10

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