Supramolecular ion channels from a transmembrane bischolic acid derivative showing two discrete conductances

被引：43

作者：

Yoshii, M ^{[1
]}

Yamamura, M ^{[1
]}

Satake, A ^{[1
]}

Kobuke, Y ^{[1
]}

机构：

[1] Nara Inst Sci & Technol, Grad Sch Mat Sci, Nara 6300192, Japan

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2004年 / 2卷 / 18期

关键词：

D O I：

10.1039/b406819j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bischolic acid derivative 1 linked by m-xylylene dicarbamate at the 3,3'-position was synthesized and the single ion channel properties were examined. Compound 1 showed two clearly distinct conductances, 9.5 ( type A) and 25.3 pS ( type B), under 500 mM KCl symmetric salt conditions, whereas various conductances, ranging from 5 - 20 pS, were observed in the tetramethylether analogue reported previously. Results indicate that the replacement of four methylether groups with hydroxyls at the 7, 7', 12, and 12' positions in the bischolic acid framework influences the stability of aggregated (supramolecular) ion channel structures. Ion permeability ratios (potassium/chloride and potassium/sodium) for each type of channel were also determined.

引用

页码：2619 / 2623

页数：5

共 47 条

[1]

Arndt HD, 2002, ANGEW CHEM INT EDIT, V41, P4062, DOI 10.1002/1521-3773(20021104)41:21<4062::AID-ANIE4062>3.0.CO

[2]

2-U

[3] An ion conductor derived from spermine and cholic acid [J].

Bandyopadhyay, P ;

Janout, V ;

Zhang, LH ;

Sawko, JA ;

Regen, SL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (51) :12888-12889

[4] Optical switching of ion-dipole interactions in a gramicidin channel analogue [J].

Borisenko, V ;

Burns, DC ;

Zhang, ZH ;

Woolley, GA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (27) :6364-6370

[5] Gramicidin derivatives as membrane-based pH sensors [J].

Borisenko, V ;

Zhang, ZH ;

Woolley, GA .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2002, 1558 (01) :26-33

[6] Synthesis and membrane activity of a bis(metacyclophane)bolaamphiphile [J].

Cameron, LM ;

Fyles, TM ;

Hu, CW .

JOURNAL OF ORGANIC CHEMISTRY, 2002, 67 (05) :1548-1553

[7] Self-assembling cyclic β3-peptide nanotubes as artificial transmembrane ion channels [J].

Clark, TD ;

Buehler, LK ;

Ghadiri, MR .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (04) :651-656

[8] Differential effects of temperature on E-coli and synthetic polyhydroxybutyrate/polyphosphate channels [J].

Das, S ;

Seebach, D ;

Reusch, RN .

BIOCHEMISTRY, 2002, 41 (16) :5307-5312

[9] Exploration of the structural features defining the conduction properties of a synthetic ion channel [J].

Dieckmann, GR ;

Lear, JD ;

Zhong, QF ;

Klein, ML ;

DeGrado, WF ;

Sharp, KA .

BIOPHYSICAL JOURNAL, 1999, 76 (02) :618-630

[10] The C-terminal ester of membrane anchored peptide ion channels affects anion transport [J].

Djedovic, N ;

Ferdani, R ;

Harder, E ;

Pajewska, J ;

Pajewski, R ;

Schlesinger, PH ;

Gokel, GW .

CHEMICAL COMMUNICATIONS, 2003, (23) :2862-2863

← 1 2 3 4 5 →