Supramolecular ion channels from a transmembrane bischolic acid derivative showing two discrete conductances

被引：43

作者：

Yoshii, M ^{[1
]}

Yamamura, M ^{[1
]}

Satake, A ^{[1
]}

Kobuke, Y ^{[1
]}

机构：

[1] Nara Inst Sci & Technol, Grad Sch Mat Sci, Nara 6300192, Japan

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2004年 / 2卷 / 18期

关键词：

D O I：

10.1039/b406819j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bischolic acid derivative 1 linked by m-xylylene dicarbamate at the 3,3'-position was synthesized and the single ion channel properties were examined. Compound 1 showed two clearly distinct conductances, 9.5 ( type A) and 25.3 pS ( type B), under 500 mM KCl symmetric salt conditions, whereas various conductances, ranging from 5 - 20 pS, were observed in the tetramethylether analogue reported previously. Results indicate that the replacement of four methylether groups with hydroxyls at the 7, 7', 12, and 12' positions in the bischolic acid framework influences the stability of aggregated (supramolecular) ion channel structures. Ion permeability ratios (potassium/chloride and potassium/sodium) for each type of channel were also determined.

引用

页码：2619 / 2623

页数：5

共 47 条

[31]

MITSUNAGA M, 2002, J SUPRAMOL CHEM, V2, P39

[32] Structure-function study on a de novo synthetic hydrophobic ion channel [J].

Qi, Z ;

Sokabe, M ;

Donowaki, K ;

Ishida, H .

BIOPHYSICAL JOURNAL, 1999, 76 (02) :631-641

[33]

Renkes T, 2000, ANGEW CHEM INT EDIT, V39, P2512, DOI 10.1002/1521-3773(20000717)39:14<2512::AID-ANIE2512>3.3.CO

[34]

2-C

[35]

RICCARDIS FD, 2002, CHEM COMMUN, P3066

[36] Synthetic multifunctional pores:: deletion and inversion of anion/cation selectivity using pM and pH [J].

Sakai, N ;

Sordé, N ;

Das, G ;

Perrottet, P ;

Gerard, D ;

Matile, S .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2003, 1 (07) :1226-1231

[37] Recognition of polarized lipid bilayers by p-oligophenyl ion channels:: From push-pull rods to push-pull barrels [J].

Sakai, N ;

Matile, S .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (07) :1184-1185

[38] Modulating ion channel properties of transmembrane peptide nanotubes through heteromeric supramolecular assemblies [J].

Sánchez-Ouesada, J ;

Isler, MP ;

Ghadiri, MR .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (34) :10004-10005

[39] The design, synthesis and characterisation of channel-forming peptides [J].

Sanderson, JM ;

Yazdani, S .

CHEMICAL COMMUNICATIONS, 2002, (10) :1154-1155

[40] Chloride transport across lipid bilayers and transmembrane potential induction by an oligophenoxyacetamide [J].

Sidorov, V ;

Kotch, FW ;

Kuebler, JL ;

Lam, YF ;

Davis, JT .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (10) :2840-2841

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