Monitoring of occupational exposure to tetrachloroethene by analysis for unmetabolized tetrachloroethene in blood and urine in comparison with urinalysis for trichloroacetic acid

被引:22
作者
Furuki, K
Ukai, H
Okamoto, S
Takada, S
Kawai, T
Miyama, Y
Mitsuyoshi, K
Zhang, ZW
Higashikawa, K
Ikeda, M
机构
[1] Kyoto Ind Hlth Assoc, Nakagyo Ku, Kyoto 6048472, Japan
[2] Osaka Occupat Hlth Serv Ctr, Osaka, Japan
[3] Kyoto Womens Univ, Kyoto, Japan
关键词
biological monitoring; blood analysis; diffusive sampling; head-space GC; tetrachloroethene; urinalysis;
D O I
10.1007/s004200050421
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Objective: The present study was initiated to examine a quantitative relationship between tetrachloroethene (TETRA) in blood and urine with TETRA in air, and to compare TETRA in blood or urine with trichloroacetic acid (TCA) in urine as exposure markers. Methods: In total, 44 workers (exposed to TETRA during automated, continuous cloth-degreasing operations), and ten non-exposed subjects volunteered to participate in the study. The exposure to vapor was monitored by diffusive sampling. The amounts of TETRA and TCA in end-of-shift blood and urine samples were measured by either head-space gas chromatography (HS-GC) or automated methylation followed by HS-GC. The correlation was examined by regression analysis. Results: The maximum time-weighted average (TWA) concentration for TETRA-exposure was 46 ppm. Regression analysis for correlation of TETRA in blood, TETRA in urine and TCA in urine, with TETRA in air, showed that the coefficient was largest for the correlation between TETRA in air and TETRA in blood. The TETRA in blood, in urine and in air correlated mutually, whereas TCA in urine correlated more closely with TETRA in blood than with TETRA in urine. The TCA values determined by colorimetry and by the GC method were very similar. The biological marker levels at a hypothetical exposure of 25 ppm TETRA were substantially higher in the present study than were the levels reported in the literature. Possible reasons are discussed. Conclusions: Blood TETRA is the best marker of occupational exposure to TETRA, being superior to the traditional marker, urinary TCA.
引用
收藏
页码:221 / 227
页数:7
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