Efficient solid-phase synthesis of 4,5-dihydro-1,2,4-triazin-6(1H)-ones

被引：9

作者：

Boeglin, D

Cantel, S

Martinez, J

Fehrentz, JA

机构：

[1] Univ Montpellier 1, CNRS, Fac Pharm, UMR 5810,LAPP, F-34093 Montpellier 5, France

[2] Univ Montpellier 2, CNRS, Fac Pharm, UMR 5810,LAPP, F-34093 Montpellier 5, France

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 03期

关键词：

Lawesson's reagent; 4,5-dihydrotriazin-6-one; thioamide; cyclocleavage;

D O I：

10.1016/S0040-4039(02)02591-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new and easy protocol for the formation of substituted 4,5-dihydro-1,2,4-triazin-6(1H)-ones was developed on solid support. The heterocyclic compounds were formed by nucleophilic reaction of hydrazine on thioamide esters. As cyclization was concomitant with cleavage from the support, substituted 4,5-dihydrotriazinones were obtained in high purity. (C) 2002 Elsevier Science Ltd. All rights reserved.

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收藏

页码：459 / 462

页数：4

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