Toward amide-linked RNA mimics:: Total synthesis of 3′-C branched uridine azido acid via an ene-Iodolactonization approach

被引：27

作者：

Rozners, E ^{[1
]}

Liu, Y ^{[1
]}

机构：

[1] Northeastern Univ, Dept Chem & Chem Biol, Boston, MA 02115 USA

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 02期

关键词：

D O I：

10.1021/ol027229z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A novel synthesis of 3'-C branched uridine azido acid has been accomplished by a sequence of stereoselective ene and iodolactonization reactions. Compared to traditional routes that start from carbohydrates, the present methodology is more flexible and can be further optimized by incorporation of novel future developments of synthetic chemistry. Because the key chemistry does not involve the 3'-C substituent, our route is a general approach to X-C alkyl nucleoside analogues.

引用

页码：181 / 184

页数：4

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