Amide backbones with conformationally restricted furanose rings: Highly improved affinity of the modified oligonucleotides for their RNA complements

被引：61

作者：

DeMesmaeker, A

Lesueur, C

Bevierre, MO

Waldner, A

Fritsch, V

Wolf, RM

机构：

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1996年 / 35卷 / 23-24期

关键词：

amides; antisense; oligonucleotides; deoxysugars; molecular modeling; nucleic acids;

D O I：

10.1002/anie.199627901

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页码：2790 / 2794

页数：5

共 41 条

[1] AN APPROACH TO THE STRUCTURE DETERMINATION OF NUCLEIC-ACID ANALOGS HYBRIDIZED TO RNA - NMR-STUDIES OF A DUPLEX BETWEEN 2'-OME RNA AND AN OLIGONUCLEOTIDE CONTAINING A SINGLE AMIDE BACKBONE MODIFICATION [J].

BLOMMERS, MJJ ;

PIELES, U ;

DEMESMAEKER, A .

NUCLEIC ACIDS RESEARCH, 1994, 22 (20) :4187-4194

[2] PREPARATION, CHARACTERIZATION AND BINDING-PROPERTIES OF AN OLIGODEOXYNUCLEOTIDE CONTAINING THE 3'-RIBOTHIOFORMACETAL PHOSPHATE ANALOG [J].

CAO, XD ;

MATTEUCCI, MD .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1994, 4 (06) :807-810

[3] PHENYLSULFENYL D-RIBOFURANOSIDES AS EFFICIENT RIBOSYL DONORS - APPLICATION TO THE SYNTHESIS OF [1'-C-13]-(DEOXY)NUCLEOSIDES [J].

CHANTELOUP, L ;

BEAU, JM .

TETRAHEDRON LETTERS, 1992, 33 (37) :5347-5350

[4]

CROOKE ST, 1992, ANNU REV PHARMACOL, V32, P329

[5]

De Mesmaeker A., 1994, ANGEW CHEM, V106, P237, DOI DOI 10.1002/ANGE.19941060230

[6] BACKBONE MODIFICATIONS IN OLIGONUCLEOTIDES AND PEPTIDE NUCLEIC-ACID SYSTEMS [J].

DEMESMAEKER, A ;

ALTMANN, KH ;

WALDNER, A ;

WENDEBORN, S .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 1995, 5 (03) :343-355

[7] AMIDES AS A NEW-TYPE OF BACKBONE MODIFICATION IN OLIGONUCLEOTIDES [J].

DEMESMAEKER, A ;

WALDNER, A ;

LEBRETON, J ;

HOFFMANN, P ;

FRITSCH, V ;

WOLF, RM ;

FREIER, SM .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1994, 33 (02) :226-229

[8] ANTISENSE OLIGONUCLEOTIDES [J].

DEMESMAEKER, A ;

HANER, R ;

MARTIN, P ;

MOSER, HE .

ACCOUNTS OF CHEMICAL RESEARCH, 1995, 28 (09) :366-374

[9] SYNTHESIS OF THYMIDINE DIMERS CONTAINING A NEW INTERNUCLEOSIDIC AMIDE LINKAGE AND THEIR INCORPORATION INTO OLIGODEOXYRIBONUCLEOTIDES [J].

DENAPOLI, L ;

IADONISI, A ;

MONTESARCHIO, D ;

VARRA, M ;

PICCIALLI, G .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (15) :1647-1652

[10] OLIGONUCLEOTIDES WITH NOVEL, CATIONIC BACKBONE SUBSTITUENTS - AMINOETHYLPHOSPHONATES [J].

FATHI, R ;

HUANG, Q ;

COPPOLA, G ;

DELANEY, W ;

TEASDALE, R ;

KRIEG, AM ;

COOK, AF .

NUCLEIC ACIDS RESEARCH, 1994, 22 (24) :5416-5424

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