SYNTHESIS OF THYMIDINE DIMERS CONTAINING A NEW INTERNUCLEOSIDIC AMIDE LINKAGE AND THEIR INCORPORATION INTO OLIGODEOXYRIBONUCLEOTIDES

被引：13

作者：

DENAPOLI, L

IADONISI, A

MONTESARCHIO, D

VARRA, M

PICCIALLI, G

机构：

[1] Dipartimento di Chimica Organica e Biologica, Università di Napoli Federico II, I-80134 Napoli

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 15期

关键词：

D O I：

10.1016/0960-894X(95)00279-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of thymidine dimers 5a,b containing a chiral carbon in the propionamide internucleosidic linkage is described. These new epimeric dimers were incorporated in oligodeoxyribonucleotides and the melting temperature (Tm) with complementary DNA and RNA as well as the resistence of the single strand against exonuclease were determined.

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页码：1647 / 1652

页数：6

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