HLA-A*24020102L in the UK blood donor population

被引:5
作者
Dunn, PPJ
Turton, JR
Downing, J
Williams, S
Navarrete, CV
Darke, C
机构
[1] Natl Blood Serv, DNA Reference Lab, British Bone Marrow Registry, Bristol, Avon, England
[2] Welsh Blood Serv, Welsh Transplantat & Immunogenet Lab, Cardiff, S Glam, Wales
[3] Natl Blood Serv, London, England
来源
TISSUE ANTIGENS | 2004年 / 63卷 / 06期
关键词
HLA-A*24020102L; expression variant; haplotype; frequency;
D O I
10.1111/j.0001-2815.2004.00233.x
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The low-expression allele HLA-A*24020102L was identified on a likely haplotype bearing B*55, Cw*01 during the investigation of nine cases (four families and five unrelated subjects) of HLA-A*24 lacking the A24 specificity. A search was made of 70,007 HLA-A, HLA-B, and HLA-C DNA-based typed largely northwestern European Caucasoid blood donors on the British Bone Marrow Registry and Welsh Bone Marrow Donor Registry panels for phenotypes possessing A*24, B*55, Cw*01. Fifty three were found, and 12 of these were subsequently shown to possess A*24020102L by sequence-based typing or polymerase chain reaction with sequence-specific primers. This indicated that the likely A*24, B*55, Cw*01 haplotype has a frequency of 0.000378 in the UK and that approximately 22.6% of these will possess A*24020102L. Consequently, HLA-A*24020102L, B*55, Cw*01 is a principal A*24020102L-bearing haplotype, and the minimum carriage and gene frequencies of A*24020102L are 0.017% and 0.000086, respectively, in UK blood donors.
引用
收藏
页码:589 / 591
页数:3
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