Modulation of signalling by sprouty: A developing story

被引：315

作者：

Kim, HJ

Bar-Sagi, D ^{[1
]}

机构：

[1] SUNY Stony Brook, Dept Mol Genet & Microbiol, Stony Brook, NY 11794 USA

[2] SUNY Stony Brook, Grad Program Mol & Cellular Biol, Stony Brook, NY 11794 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2004年 / 5卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrm1400

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Sprouty proteins are evolutionarily conserved inducible inhibitors of signalling by receptor tyrosine kinases. They have been implicated in negative-feedback interactions that impart spatial and temporal constraints to intracellular signals. The repressive function of Sprouty proteins targets several receptor-tyrosine-kinase-dependent signalling steps, indicating that their activities might have broader biological consequences than was initially anticipated.

引用

页码：441 / 450

页数：10

共 63 条

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