A Mutual Regulation between Cell-Cell Adhesion and N-Glycosylation: Implication of the Bisecting GlcNAc for Biological Functions

被引：63

作者：

Gu, Jianguo ^{[1
]}

Sato, Yuya

Kariya, Yoshinobu

Isaji, Tomoya

Taniguchi, Naoyuki ^{[2
,3
]}

Fukuda, Tomohiko

机构：

[1] Tohoku Pharmaceut Univ, Div Regulatory Glycobiol, Aoba Ku, Sendai, Miyagi 9818558, Japan

[2] Osaka Univ, Inst Microbial Dis, Dept Dis Glycomcis, Suita, Osaka 5650871, Japan

[3] RIKEN, Dis Glyc Team, Syst Glycobiol Grp, Wako, Saitama 3510198, Japan

来源：

JOURNAL OF PROTEOME RESEARCH | 2009年 / 8卷 / 02期

基金：

日本科学技术振兴机构;

关键词：

Bisecting GlcNAc; cell adhesion; E-cadherin; N-glycosylation; GnT-III; integrin; EPIDERMAL-GROWTH-FACTOR; ACETYLGLUCOSAMINYLTRANSFERASE-III GENE; E-CADHERIN; FACTOR RECEPTOR; ALPHA-CATENIN; DOWN-REGULATION; CDNA CLONING; EXPRESSION; OLIGOSACCHARIDES; BINDING;

D O I：

10.1021/pr800674g

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Changes in oligosaccharide structures are associated with numerous physiological and pathological events. E-cadherin-mediated cell-cell adhesion is believed to be both temporally and spatially regulated during development, and represents a key step in the acquisition of the invasive phenotype for many tumors. Here, we focus mainly on a mutual regulation between E-cadherin-mediated cell-cell adhesion and N-acetylglucosaminyltransferase III (GnT-III) expression, and discuss its implications for biological functions.

引用

页码：431 / 435

页数：5

共 60 条

[1] N-acetylglucosaminyltransferase III expression is regulated by cell-cell adhesion via the E-cadherin-catenin-actin complex [J].

Akama, Ryota ;

Sato, Yuya ;

Kariya, Yoshinobu ;

Isaji, Tomoya ;

Fukuda, Tomohiko ;

Lu, Lianghao ;

Taniguchi, Naoyuki ;

Ozawa, Masayuki ;

Gu, Jianguo .

PROTEOMICS, 2008, 8 (16) :3221-3228

[2]

Asada M, 1997, CANCER RES, V57, P1073

[3] Rac activation upon cell-cell contact formation is dependent on signaling from the epidermal growth factor receptor [J].

Betson, M ;

Lozano, E ;

Zhang, JK ;

Braga, VMM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (40) :36962-36969

[4] Cadherins and catenins in breast cancer [J].

Cowin, P ;

Rowlands, TM ;

Hatsell, SJ .

CURRENT OPINION IN CELL BIOLOGY, 2005, 17 (05) :499-508

[5]

Dennis JW, 1999, BIOESSAYS, V21, P412, DOI 10.1002/(SICI)1521-1878(199905)21:5<412::AID-BIES8>3.0.CO

[6]

2-5

[7] α-catenin is a molecular switch that binds E-cadherin-β-catenin and regulates actin-filament assembly [J].

Drees, F ;

Pokutta, S ;

Yamada, S ;

Nelson, WJ ;

Weis, WI .

CELL, 2005, 123 (05) :903-915

[8]

DWEK RA, 1995, BIOCHEM SOC T, V23, P1

[9]

Granovsky M, 2000, NAT MED, V6, P306

[10] β1,4-N-Acetylglucosaminyltransferase III down-regulates neurite outgrowth induced by costimulation of epidermal growth factor and integrins through the Ras/ERK signaling pathway in PC12 cells [J].

Gu, JG ;

Zhao, YY ;

Isaji, T ;

Shibukawa, Y ;

Ihara, H ;

Takahashi, M ;

Ikeda, Y ;

Miyoshi, E ;

Honke, K ;

Taniguchi, N .

GLYCOBIOLOGY, 2004, 14 (02) :177-186

← 1 2 3 4 5 6 →