A Mutual Regulation between Cell-Cell Adhesion and N-Glycosylation: Implication of the Bisecting GlcNAc for Biological Functions

被引：63

作者：

Gu, Jianguo ^{[1
]}

Sato, Yuya

Kariya, Yoshinobu

Isaji, Tomoya

Taniguchi, Naoyuki ^{[2
,3
]}

Fukuda, Tomohiko

机构：

[1] Tohoku Pharmaceut Univ, Div Regulatory Glycobiol, Aoba Ku, Sendai, Miyagi 9818558, Japan

[2] Osaka Univ, Inst Microbial Dis, Dept Dis Glycomcis, Suita, Osaka 5650871, Japan

[3] RIKEN, Dis Glyc Team, Syst Glycobiol Grp, Wako, Saitama 3510198, Japan

来源：

JOURNAL OF PROTEOME RESEARCH | 2009年 / 8卷 / 02期

基金：

日本科学技术振兴机构;

关键词：

Bisecting GlcNAc; cell adhesion; E-cadherin; N-glycosylation; GnT-III; integrin; EPIDERMAL-GROWTH-FACTOR; ACETYLGLUCOSAMINYLTRANSFERASE-III GENE; E-CADHERIN; FACTOR RECEPTOR; ALPHA-CATENIN; DOWN-REGULATION; CDNA CLONING; EXPRESSION; OLIGOSACCHARIDES; BINDING;

D O I：

10.1021/pr800674g

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Changes in oligosaccharide structures are associated with numerous physiological and pathological events. E-cadherin-mediated cell-cell adhesion is believed to be both temporally and spatially regulated during development, and represents a key step in the acquisition of the invasive phenotype for many tumors. Here, we focus mainly on a mutual regulation between E-cadherin-mediated cell-cell adhesion and N-acetylglucosaminyltransferase III (GnT-III) expression, and discuss its implications for biological functions.

引用

页码：431 / 435

页数：5

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