Bioactive constituents of Morus australis and Broussonetia papyrifera

被引：71

作者：

Ko, HH

Yu, SM

Ko, FN

Teng, CM

Lin, CN

机构：

[1] KAOHSIUNG MED COLL, SCH PHARM, KAOHSIUNG 807, TAIWAN

[2] CHANG GUNG MED COLL, DEPT PHARMACOL, TAYUAN 333, TAIWAN

[3] NATL TAIWAN UNIV, COLL MED, INST PHARMACOL, TAIPEI 100, TAIWAN

来源：

JOURNAL OF NATURAL PRODUCTS | 1997年 / 60卷 / 10期

关键词：

D O I：

10.1021/np970186o

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The biological activities of the active principles of two plants in the Moraceae have been investigated. A new prenylflavonoid, australone A (1), and a new triterpenoid, 3 beta-[(m-methoxybenzoyl)oxy]urs-12-en-28-oic acid (2) were isolated from the root bark of Morus australis, and their structures determined by spectroscopic methods. Also isolated from this plant were seven known compounds, morusin (3), kuwanon C (4), betulinic acid, beta-amyrin, quercetin, ursolic acid, and compound A. Morusin (3) showed significant effects on arachidonic acid-, collagen-, and PAF-induced platelet aggregation, while kuwanon C (4) was active in the arachidonic acid- and PAF-induced platelet aggregation assays. In biological work on a second plant, Broussonetia papyrifera, broussoflavonols F (5) and G (6), broussoflavan A (7), and broussoaurone A (8) potently inhibited Fe2+-induced lipid oxidation in rat-brain homogenate. Compounds 5-7 also significantly inhibited the proliferation of rat vascular smooth muscle cells.

引用

页码：1008 / 1011

页数：4

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