Large-Scale Structural Biology of the Human Proteome

被引：28

作者：

Edwards, Aled ^{[1
]}

机构：

[1] Univ Toronto, Banting & Best Dept Med Res, Toronto, ON M5G 1L6, Canada

来源：

ANNUAL REVIEW OF BIOCHEMISTRY | 2009年 / 78卷

基金：

英国惠康基金; 美国国家卫生研究院;

关键词：

chemical biology; human proteins; structural genomics; ORPHAN NUCLEAR RECEPTORS; CRYSTAL-STRUCTURE; TYROSINE PHOSPHATASES; KINASE INHIBITORS; HISTONE MODIFICATIONS; NERVOUS-SYSTEM; WEB SERVER; CELL FATE; GENOMICS; FAMILY;

D O I：

10.1146/annurev.biochem.78.070907.103305

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The large-scale structural biology projects that target human proteins focus predominantly on the catalytic domains of potential therapeutic targets and the domains of human proteins that mediate protein-protein and protein-small-molecule interactions. Their main scientific objective is to elucidate the molecular basis for specificity and selectivity of function within large protein families of therapeutic interest, such as kinases, phosphatases, and proteins involved in epigenetic regulation. Half of the unique human protein structures determined in the past three years derive from these initiatives.

引用

页码：541 / 568

页数：28

共 168 条

[51] Protein production and purification [J].

Graslund, Susanne ;

Nordlund, Paer ;

Weigelt, Johan ;

Bray, James ;

Hallberg, B. Martin ;

Gileadi, Opher ;

Knapp, Stefan ;

Oppermann, Udo ;

Arrowsmith, Cheryl ;

Hui, Raymond ;

Ming, Jinrong ;

dhe-Paganon, Sirano ;

Park, Hee-won ;

Savchenko, Alexei ;

Yee, Adelinda ;

Edwards, Aled ;

Vincentelli, Renaud ;

Cambillau, Christian ;

Kim, Rosalind ;

Kim, Sung-Hou ;

Rao, Zihe ;

Shi, Yunyu ;

Terwilliger, Thomas C. ;

Kim, Chang-Yub ;

Hung, Li-Wei ;

Waldo, Geoffrey S. ;

Peleg, Yoav ;

Albeck, Shira ;

Unger, Tamar ;

Dym, Orly ;

Prilusky, Jaime ;

Sussman, Joel L. ;

Stevens, Ray C. ;

Lesley, Scott A. ;

Wilson, Ian A. ;

Joachimiak, Andrzej ;

Collart, Frank ;

Dementieva, Irina ;

Donnelly, Mark I. ;

Eschenfeldt, William H. ;

Kim, Youngchang ;

Stols, Lucy ;

Wu, Ruying ;

Zhou, Min ;

Burley, Stephen K. ;

Emtage, J. Spencer ;

Sauder, J. Michael ;

Thompson, Devon ;

Bain, Kevin ;

Luz, John .

NATURE METHODS, 2008, 5 (02) :135-146

[52] The structure of the cell cycle protein Cdc14 reveals a proline-directed protein phosphatase [J].

Gray, CH ;

Good, VM ;

Tonks, NK ;

Barford, D .

EMBO JOURNAL, 2003, 22 (14) :3524-3535

[53] Getting in the Ring Proline-Directed Substrate Specificity in the Cell Cycle Proteins Cdc14 and CDK2-CyclinA3 [J].

Gray, Christopher H. ;

Barford, David .

CELL CYCLE, 2003, 2 (06) :500-502

[54] The CATH domain structure database: new protocols and classification levels give a more comprehensive resource for exploring evolution [J].

Greene, Lesley H. ;

Lewis, Tony E. ;

Addou, Sarah ;

Cuff, Alison ;

Dallman, Tim ;

Dibley, Mark ;

Redfern, Oliver ;

Pearl, Frances ;

Nambudiry, Rekha ;

Reid, Adam ;

Sillitoe, Ian ;

Yeats, Corin ;

Thornton, Janet M. ;

Orengo, Christine A. .

NUCLEIC ACIDS RESEARCH, 2007, 35 :D291-D297

[55] Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9 [J].

Greiner, D ;

Bonaldi, T ;

Eskeland, R ;

Roemer, E ;

Imhof, A .

NATURE CHEMICAL BIOLOGY, 2005, 1 (03) :143-145

[56] Rabs and their effectors: Achieving specificity in membrane traffic [J].

Grosshans, Blanka L. ;

Ortiz, Darinel ;

Novick, Peter .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (32) :11821-11827

[57]

Guntert Peter, 2004, Methods Mol Biol, V278, P353

[58] An integrated approach to structural genomics [J].

Heinemann, U ;

Frevert, J ;

Hofmann, KP ;

Illing, G ;

Maurer, C ;

Oschkinat, H ;

Saenger, W .

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 2000, 73 (05) :347-362

[59] Synchrotron crystallography [J].

Hendrickson, WA .

TRENDS IN BIOCHEMICAL SCIENCES, 2000, 25 (12) :637-643

[60] RGS2/G0S8 is a selective inhibitor of Gqα function [J].

Heximer, SP ;

Watson, N ;

Linder, ME ;

Blumer, KJ ;

Hepler, JR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (26) :14389-14393

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