Polymeric Materials for Gene Delivery and DNA Vaccination

被引：209

作者：

Nguyen, David N. ^{[1
]}

Green, Jordan J. ^{[1
]}

Chan, Juliana M. ^{[1
]}

Longer, Robert ^{[1
]}

Anderson, Daniel G. ^{[1
]}

机构：

[1] MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

来源：

ADVANCED MATERIALS | 2009年 / 21卷 / 08期

基金：

美国国家科学基金会;

关键词：

ENHANCE IMMUNE-RESPONSE; CYTOTOXIC T-LYMPHOCYTE; PLASMID DNA; IN-VIVO; CATIONIC MICROPARTICLES; DENDRITIC CELLS; ANTIGEN PRESENTATION; POLY(ORTHO ESTERS); BIODEGRADABLE MICROPARTICLES; INTRAMUSCULAR INJECTION;

D O I：

10.1002/adma.200801478

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Gene delivery holds great potential for the treatment of many different diseases. Vaccination with DNA holds particular promise, and may provide a solution to many technical challenges that hinder traditional vaccine systems including rapid development and production and induction of robust cell-mediated immune responses. However, few candidate DNA vaccines have progressed past preclinical development and none have been approved for human use. This Review focuses on the recent progress and challenges facing materials design for nonviral DNA vaccine drug delivery systems. In particular, we highlight work on new polymeric materials and their effects on protective immune activation, gene delivery, and current efforts to optimize polymeric delivery systems for DNA vaccination.

引用

页码：847 / 867

页数：21

共 226 条

[1] Formulating poly(lactide-co-glycolide) particles for plasmid DNA delivery [J].

Abbas, Aiman O. ;

Donovan, Maureen D. ;

Salem, Aliasger K. .

JOURNAL OF PHARMACEUTICAL SCIENCES, 2008, 97 (07) :2448-2461

[2] Parallel synthesis and biophysical characterization of a degradable polymer library for gene delivery [J].

Akinc, A ;

Lynn, DM ;

Anderson, DG ;

Langer, R .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (18) :5316-5323

[3] Exploring polyethylenimine-mediated DNA transfection and the proton sponge hypothesis [J].

Akinc, A ;

Thomas, M ;

Klibanov, AM ;

Langer, R .

JOURNAL OF GENE MEDICINE, 2005, 7 (05) :657-663

[4]

Akinc A, 2002, BIOTECHNOL BIOENG, V78, P503, DOI 10.1002/bit.20215

[5] A combinatorial library of lipid-like materials for delivery of RNAi therapeutics [J].

Akinc, Akin ;

Zumbuehl, Andreas ;

Goldberg, Michael ;

Leshchiner, Elizaveta S. ;

Busini, Valentina ;

Hossain, Naushad ;

Bacallado, Sergio A. ;

Nguyen, David N. ;

Fuller, Jason ;

Alvarez, Rene ;

Borodovsky, Anna ;

Borland, Todd ;

Constien, Rainer ;

de Fougerolles, Antonin ;

Dorkin, J. Robert ;

Jayaprakash, K. Narayanannair ;

Jayaraman, Muthusamy ;

John, Matthias ;

Koteliansky, Victor ;

Manoharan, Muthiah ;

Nechev, Lubomir ;

Qin, June ;

Racie, Timothy ;

Raitcheva, Denitza ;

Rajeev, Kallanthottathil G. ;

Sah, Dinah W. Y. ;

Soutschek, Juergen ;

Toudjarska, Ivanka ;

Vornlocher, Hans-Peter ;

Zimmermann, Tracy S. ;

Langer, Robert ;

Anderson, Daniel G. .

NATURE BIOTECHNOLOGY, 2008, 26 (05) :561-569

[6] Pathogen recognition and innate immunity [J].

Akira, S ;

Uematsu, S ;

Takeuchi, O .

CELL, 2006, 124 (04) :783-801

[7] Biodegradable mucoadhesive particulates for nasal and pulmonary antigen and DNA delivery [J].

Alpar, HO ;

Somavarapu, S ;

Atuah, KN ;

Bramwell, V .

ADVANCED DRUG DELIVERY REVIEWS, 2005, 57 (03) :411-430

[8] A multivalent minigene vaccine, containing B-cell, cytotoxic T-lymphocyte, and T-h epitopes from several microbes, induces appropriate responses in vivo and confers protection against more than one pathogen [J].

An, LL ;

Whitton, JL .

JOURNAL OF VIROLOGY, 1997, 71 (03) :2292-2302

[9] Semi-automated synthesis and screening of a large library of degradable cationic polymers for gene delivery [J].

Anderson, DG ;

Lynn, DM ;

Langer, R .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (27) :3153-3158

[10] Structure/property studies of polymeric gene delivery using a library of poly(β-amino esters) [J].

Anderson, DG ;

Akinc, A ;

Hossain, N ;

Langer, R .

MOLECULAR THERAPY, 2005, 11 (03) :426-434

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