Premithramycinone G, an early shunt product of the mithramycin biosynthetic pathway accumulated upon inactivation of oxygenase MtmOII

被引：19

作者：

Abdelfattah, Mohamed S. ^{[1
]}

Rohr, Jurgen ^{[1
]}

机构：

[1] Univ Kentucky, Coll Pharm, Dept Pharmaceut Sci, Lexington, KY 40536 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 34期

关键词：

aureolic acids; enzyme complexes; mithramycin; oxidoreductases; polyketides;

D O I：

10.1002/anie.200600511

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The unusual dodecaketide premithramycinone G (see formula), which possesses a five-membered ring with two ketide chains in its tetracyclic structure, was accumulated upon inactivation of an early acting oxygenase of the mithramycin biosynthetic pathway. This unexpected structure allows novel hypothetic conclusions to be drawn regarding the early mithramycin pathway and suggestions for the involvement of three previously unassigned oxygenases. (Chemical Equation Presented). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5685 / 5689

页数：5

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