Expression of the DNA mismatch repair proteins hMLH1 and hPMS2 in normal human tissues

被引：29

作者：

Fink, D ^{[1
]}

Nebel, S ^{[1
]}

Aebi, S ^{[1
]}

Zheng, H ^{[1
]}

Kim, HK ^{[1
]}

Christen, RD ^{[1
]}

Howell, SB ^{[1
]}

机构：

[1] UNIV CALIF SAN DIEGO,CTR CANC,LA JOLLA,CA 92093

来源：

BRITISH JOURNAL OF CANCER | 1997年 / 76卷 / 07期

关键词：

DNA mismatch repair; hMLH1; hPMS2;

D O I：

10.1038/bjc.1997.480

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

hMLH1 and hPMS2 are part of the DNA mismatch repair complex. Mutations in these genes have been linked to hereditary non-polyposis colon cancer; they also occur in a variety of sporadic cancers. Western blot analysis and immunohistochemistry demonstrated that hMLH1 and hPMS2 are widely expressed nuclear proteins with a distribution pattern very similar to that previously described for hMSH2. These observations showing similar localization of hMLH1 and hPMS2 with hMSH2 are consistent with the biochemical function of these proteins in DNA mismatch repair.

引用

页码：890 / 893

页数：4