Suppression effect of Cinnamomum cassia bark-derived component on nitric oxide synthase

被引：90

作者：

Lee, HS ^{[1
]}

Kim, BS

Kim, MK

机构：

[1] Chonbuk Natl Univ, Res Ctr Ind Dev Biofood Mat, Chonju 561756, South Korea

[2] Chonbuk Natl Univ, Coll Agr, Inst Agr Sci & Technol, Chonju 561756, South Korea

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2002年 / 50卷 / 26期

关键词：

NO production; Cinnamomum cassia; cinnamaldehyde; inducible nitric oxide synthase; supression;

D O I：

10.1021/jf020751f

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

The inhibitory effects of Cinnamomum cassia bark-derived material on nitric oxide (NO) production in RAW 264.7 cells was determined through the evaluation of NO production and expression of inducible nitric oxide and compared to the effects of three commercially available compounds, cinnamyl alcohol, cinnamic acid, and eugenol. The biologically active constituents of C. cassia extract were characterized as trans-cinnamaldehyde by spectral analysis. The inhibitory effects varied with both chemical and concentration used. Potent inhibitory effects of cinnamaldehyde against NO production were 81.5 and 71.7% at 1.0 and 0.5 mug/muL, respectively, and a 41.2% inhibitory effect, was revealed at 0.1 mug/muL. However, little or no activity was observed for cinnamic acid and eugenol. Suppression effects of cinnamaldehyde on inducible nitric oxide synthase expression were revealed by Western blot analysis. As a naturally occurring therapeutic agent, trans-cinnamaldehyde could be useful for developing new types of NO inhibitors.

引用

页码：7700 / 7703

页数：4

共 32 条

[11]

KIM MK, 2001, AGR CHEM BIOTECHNOL, V44, P185

[12]

KIM MK, 2000, AGR CHEM BIOTECHNOL, V43, P54

[13]

Kim Moo-Key, 2002, Agricultural Chemistry and Biotechnology, V45, P84

[14] Microtubule-disrupting agents inhibit nitric oxide production in murine peritoneal macrophages stimulated with lipopolysaccharide or paclitaxel (Taxol) [J].

Kirikae, T ;

Kirikae, F ;

Oghiso, Y ;

Nakano, M .

INFECTION AND IMMUNITY, 1996, 64 (08) :3379-3384

[15] Cinnamaldehyde inhibits lymphocyte proliferation and modulates T-cell differentiation [J].

Koh, WS ;

Yoon, SY ;

Kwon, BM ;

Jeong, TC ;

Nam, KS ;

Han, MY .

INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY, 1998, 20 (11) :643-660

[16] Antipyretic activity of cinnamyl derivatives and related compounds in influenza virus-infected mice [J].

Kurokawa, M ;

Kumeda, CA ;

Yamamura, J ;

Kamiyama, T ;

Shiraki, K .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1998, 348 (01) :45-51

[17] Growth-inhibiting effects of Cinnamomum cassia bark-derived materials on human intestinal bacteria [J].

Lee, HS ;

Ahn, YJ .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1998, 46 (01) :8-12

[18]

Lee MR, 2000, MIN SOC SER, V9, P77

[19] p53, the cellular gatekeeper for growth and division [J].

Levine, AJ .

CELL, 1997, 88 (03) :323-331

[20] Protective effects of mercaptoethylguanidine, a selective inhibitor of inducible nitric oxide synthase, in ligature-induced periodontitis in the rat [J].

Lohinai, Z ;

Benedek, P ;

Fehér, E ;

Györfi, A ;

Rosivall, L ;

Fazekas, A ;

Salzman, AL ;

Szabó, C .

BRITISH JOURNAL OF PHARMACOLOGY, 1998, 123 (03) :353-360

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