A convenient preparation of 1,2,3-tri-O-acetyl-β-D-ribofuranose by enzymatic regioselective 5-O-deacetylation of the peracetylated ribofuranose

被引：18

作者：

Chien, TC ^{[1
]}

Chern, JW ^{[1
]}

机构：

[1] Natl Taiwan Univ, Coll Med, Sch Pharm, Sect 1, Taipei 100, Taiwan

来源：

CARBOHYDRATE RESEARCH | 2004年 / 339卷 / 06期

关键词：

lipase; regioselective; deacetylation; deprotection; ribofuranose;

D O I：

10.1016/j.carres.2004.01.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The lipase from Candida rugosa (Sigma) was used to catalyze the regioselective deacetylation at the 5-position of 1,2,3,5-tetra-O-acetyl-beta-D-ribofuranose on a preparative scale. Enzymatic deacetylation provides a convenient one-step preparation of 1,2.3-tri-O-acetyl-beta-D-ribofuranose. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1215 / 1217

页数：3

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