Hepatic transport systems

被引：23

作者：

Ferenci, P

Zollner, G

Trauner, M

机构：

[1] Univ Vienna, Dept Internal Med 4, A-1090 Vienna, Austria

[2] Karl Franzens Univ Graz, Dept Internal Med, Div Gastroenterol & Hepatol, Graz, Austria

来源：

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | 2002年 / 17卷

关键词：

D O I：

10.1046/j.1440-1746.17.s1.15.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The identification of the genes responsible for various genetic liver disorders lead to a better understanding of basic physiology of hepatic transport systems. In this review we focus on transport systems involved in the generation of bile and in the maintenance of copper homeostasis. Abnormal function of these transporters results in diseases like Wilson's disease, progressive familial cholestasis syndromes, Dubin-Johnson syndrome and cystic fibrosis. Beyond these well defined diseases, functional impairments of transport proteins may predispose to non-genetic diseases ranging from intrahepatic cholestasis of pregnancy to neurodegenerative disorders including Alzheimer's disease. (C) 2002 Blackwell Science Asia Pty Ltd.

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页码：S105 / S112

页数：8

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