Amyloid at the blood vessel wall

被引：38

作者：

Hardy, John ^{[1
]}

Cullen, Karen

机构：

[1] NIA, Neurogenet Lab, NIH, Bethesda, MD 20892 USA

[2] Univ Sydney, Sch Med Sci, Dept Anat & Histol, Sydney, NSW 2006, Australia

来源：

NATURE MEDICINE | 2006年 / 12卷 / 07期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/nm0706-756

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An APP gene duplication found in French families with beta-amyloidopathy suggests a link between dementia and the vasculature.

引用

页码：756 / 757

页数：3

共 12 条

[1]

CULLEN KE, NEUROBIOL AGING

[2] Histological co-localization of iron in Aβ plaques of PS/APP transgenic mice [J].

Falangola, MF ;

Lee, SP ;

Nixon, RA ;

Duff, K ;

Helpern, JA .

NEUROCHEMICAL RESEARCH, 2005, 30 (02) :201-205

[3] Amyloid double trouble [J].

Hardy, J .

NATURE GENETICS, 2006, 38 (01) :11-12

[4] AN INTEGRATIVE HYPOTHESIS CONCERNING THE PATHOGENESIS AND PROGRESSION OF ALZHEIMERS-DISEASE [J].

HARDY, JA ;

MANN, DMA ;

WESTER, P ;

WINBLAD, B .

NEUROBIOLOGY OF AGING, 1986, 7 (06) :489-502

[5] Dense-core plaques in Tg2576 and PSAPP mouse models of Alzheimer's disease are centered on vessel walls [J].

Kumar-Singh, S ;

Pirici, D ;

McGowan, E ;

Serneels, S ;

Ceuterick, C ;

Hardy, J ;

Duff, K ;

Dickson, D ;

Van Broeckhoven, C .

AMERICAN JOURNAL OF PATHOLOGY, 2005, 167 (02) :527-543

[6] Diffusible, nonfibrillar ligands derived from Aβ1-42 are potent central nervous system neurotoxins [J].

Lambert, MP ;

Barlow, AK ;

Chromy, BA ;

Edwards, C ;

Freed, R ;

Liosatos, M ;

Morgan, TE ;

Rozovsky, I ;

Trommer, B ;

Viola, KL ;

Wals, P ;

Zhang, C ;

Finch, CE ;

Krafft, GA ;

Klein, WL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (11) :6448-6453

[7] THE RELATIONSHIP BETWEEN SENILE PLAQUES AND CEREBRAL BLOOD-VESSELS IN ALZHEIMERS-DISEASE AND SENILE DEMENTIA - MORPHOLOGICAL MECHANISM OF SENILE PLAQUE PRODUCTION [J].

MIYAKAWA, T ;

SHIMOJI, A ;

KURAMOTO, R ;

HIGUCHI, Y .

VIRCHOWS ARCHIV B-CELL PATHOLOGY INCLUDING MOLECULAR PATHOLOGY, 1982, 40 (02) :121-129

[8] Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide:: a case report [J].

Nicoll, JAR ;

Wilkinson, D ;

Holmes, C ;

Steart, P ;

Markham, H ;

Weller, RO .

NATURE MEDICINE, 2003, 9 (04) :448-452

[9] APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy [J].

Rovelet-Lecrux, A ;

Hannequin, D ;

Raux, G ;

Le Meur, N ;

Laquerrière, A ;

Vital, A ;

Dumanchin, C ;

Feuillette, S ;

Brice, A ;

Vercelletto, M ;

Dubas, F ;

Frebourg, T ;

Campion, D .

NATURE GENETICS, 2006, 38 (01) :24-26

[10] The law of mass action applied to neurodegenerative disease: a hypothesis concerning the etiology and pathogenesis of complex diseases [J].

Singleton, A ;

Myers, A ;

Hardy, J .

HUMAN MOLECULAR GENETICS, 2004, 13 :R123-R126

← 1 2 →