Physical fitness and lifetime cognitive change

被引：89

作者：

Deary, Ian J.

Whalley, Lawrence J.

Batty, G. David

Starr, John M.

机构：

[1] Univ Edinburgh, Dept Psychol, Sch Philosophy Psychol & Language Sci, Edinburgh EH8 9JZ, Midlothian, Scotland

[2] Univ Aberdeen, Dept Mental Hlth, Aberdeen, Scotland

[3] MRC, Social & Publ Hlth Sci Unit, Glasgow, Lanark, Scotland

[4] Univ Edinburgh, Dept Geriatr Med, Edinburgh, Midlothian, Scotland

来源：

NEUROLOGY | 2006年 / 67卷 / 07期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1212/01.wnl.0000238520.06958.6a

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: To test the hypothesis that physical fitness is associated with more successful cognitive aging. Methods: Surviving participants (N = 460) of the Scottish Mental Survey of 1932 were tested on the same general cognitive test at age 11 and 79 years. Measures of grip strength, 6-meter walk time, and lung function (forced expiratory volume from the lungs in 1 second [FEV1]) were assessed at age 79 years. Results: A latent physical fitness trait, derived by principal components analysis of the three fitness measures, was significantly associated with successful cognitive aging. Cognitive score at age 11, sex, social class, and APOE-epsilon 4 genotype were included as covariables. Higher childhood IQ was associated with better lung function in old age. Conclusions: Physical fitness is associated with cognitive reserve. Intervention studies aimed at making older people fitter are good candidates to improve cognitive aging.

引用

页码：1195 / 1200

页数：6

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