Role of the nitric oxide pathway in κ-opioid-induced hypothermia in rats

被引:22
作者
Benamar, K
Geller, EB
Adler, MW
机构
[1] Temple Univ, Sch Med, Dept Pharmacol, Philadelphia, PA 19140 USA
[2] Temple Univ, Sch Med, Ctr Subst Abuse Res, Philadelphia, PA 19140 USA
关键词
D O I
10.1124/jpet.102.036269
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The effect of central and peripheral administration of a nitric oxide synthase inhibitor, N-nitro-L-arginine methyl ester (L-NAME), on the hypothermia induced by the selective kappa-opioid receptor agonist trans-(+/-) 3,4-dichloro-N-methyl-N-(2-[1-pyrrolidinyl]-cyclohexyl)- benzeneacetamide methane sulfate (U50,488H) was studied in male Sprague-Dawley rats. In the first series of experiments, we examined the effect of subcutaneous (s.c.) administration of L-NAME on the hypothermia induced by s.c. injection of U50,488H. L-NAME, at a dose of 50 mg/kg s.c., had no influence on body temperature (Tb). Coadministration of L-NAME (50 mg/kg, s.c.) with U50,488H (10 mg/kg, s.c.) blocked the hypothermia induced by U50,488H. In the second series of experiments, we investigated the effect of intracerebroventricular (i.c.v.) administration of L-NAME on the hypothermia induced by s.c. injection of U50,488H. L-NAME itself, given i.c.v. at a dose of 1 mg/rat, did not evoke any change in Tb. Administration of L-NAME (1 mg/rat, i.c.v.) caused a significant suppression of U50,488H hypothermia. The results indicate that either central or peripheral nitric oxide synthesis is required for the production of hypothermia induced by U50,488H.
引用
收藏
页码:375 / 378
页数:4
相关论文
共 37 条
[31]   CHARACTERIZATION OF 3 INHIBITORS OF ENDOTHELIAL NITRIC-OXIDE SYNTHASE INVITRO AND INVIVO [J].
REES, DD ;
PALMER, RMJ ;
SCHULZ, R ;
HODSON, HF ;
MONCADA, S .
BRITISH JOURNAL OF PHARMACOLOGY, 1990, 101 (03) :746-752
[32]   Inhibition of nitric oxide synthase results in a suppression of interleukin-1β-induced fever in rats [J].
Roth, J ;
Störr, B ;
Voigt, K ;
Zeisberger, E .
LIFE SCIENCES, 1998, 62 (22) :PL345-PL350
[33]   Inhibition of nitric oxide synthase produces hypothermia and depresses lipopolysaccharide fever [J].
Scammell, TE ;
Elmquist, JK ;
Saper, CB .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 1996, 271 (02) :R333-R338
[34]  
SPENCER RL, 1988, J PHARMACOL EXP THER, V246, P92
[35]   Role of nitric oxide in systemic vasopressin-induced hypothermia [J].
Steiner, AA ;
Carnio, EC ;
Antunes-Rodrigues, J ;
Branco, LGS .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 1998, 275 (04) :R937-R941
[36]   A ROLE FOR NITRIC-OXIDE IN ACTIVE THERMOREGULATORY VASODILATION [J].
TAYLOR, WF ;
BISHOP, VS .
AMERICAN JOURNAL OF PHYSIOLOGY, 1993, 264 (05) :H1355-H1359
[37]   Involvement of β-endorphin in the preoptic anterior hypothalamus during interleukin-1β-induced fever in rats [J].
Xin, L ;
Zhao, SF ;
Geller, EB ;
McCafferty, MR ;
Sterlin, GH ;
Adler, MW .
THERMOREGULATION: TENTH INTERNATIONAL SYMPOSIUM ON THE PHARMACOLOGY OF THERMOREGULATION, 1997, 813 :324-326