Oligomer synthesis and DNA/RNA recognition properties of a novel oligonucleotide backbone analog: Glucopyranosyl nucleic amide (GNA)

被引：40

作者：

Goodnow, RA

Tam, S

Pruess, DL

McComas, WW

机构：

[1] Roche Research Center, Hoffmann-La Roche, Nutley

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 18期

关键词：

D O I：

10.1016/S0040-4039(97)00611-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general solid phase synthesis is described for the construction of novel amide linked oligonucleotide analogs having the glucopyranosyl configuration via solid phase N-Fmcc-type peptide chemistry. The selective binding to DNA and RNA sequences by these oligomers is characterized by measurement of melting temperatures and related thermodynamic constants. (C) 1997 Elsevier Science Ltd.

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页码：3199 / 3202

页数：4

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