The Oxidative Stress Menace to Coronary Vasculature: Any Place for Antioxidants?

被引：22

作者：

Briasoulis, Alexandros ^{[1
]}

Tousoulis, Dimitris ^{[1
]}

Antoniades, Charalambos ^{[1
]}

Stefanadis, Christodoulos ^{[1
]}

机构：

[1] Univ Athens, Sch Med, Cardiol Unit 1, Hippokrat Hosp, Athens 16675, Greece

来源：

CURRENT PHARMACEUTICAL DESIGN | 2009年 / 15卷 / 26期

关键词：

Antioxidants; coronary artery disease; nitric oxide; endothelium; VITAMIN-E SUPPLEMENTATION; ACTIVATED RECEPTOR-GAMMA; LONG-TERM SUPPLEMENTATION; COA REDUCTASE INHIBITOR; ISCHEMIC-HEART-DISEASE; NITRIC-OXIDE; BETA-CAROTENE; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; ALPHA-TOCOPHEROL;

D O I：

10.2174/138161209789058057

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Oxidative stress is involved in the pathogenesis of atherosclerosis. A variety of antioxidants has been used in clinical studies, during the past few years, for the prevention and treatment of atherosclerosis. In small clinical studies it was found that both vitamins C and E may improve endothelial function in high risk patients. However, interventional trials have been controversial, with some positive findings, many null findings, and some suggestion of harm in certain high-risk populations. Therefore, treatment with antioxidant vitamins C and E should not be recommended for the prevention or treatment of coronary atherosclerosis. New antioxidant strategies are needed to clarify the exact role of antioxidant treatment in coronary atherosclerosis.

引用

页码：3078 / 3090

页数：13

共 118 条

[1]

VITAMIN-E REVERSES CHOLESTEROL-INDUCED ENDOTHELIAL DYSFUNCTION IN THE RABBIT CORONARY CIRCULATION [J].

ANDERSSON, TLG ;

MATZ, J ;

FERNS, GAA ;

ANGGARD, EE .

ATHEROSCLEROSIS, 1994, 111 (01) :39-45

[2]

Antoniades C, 2003, HERZ, V28, P628, DOI 10.1007/s00059-003-2417-8

[3]

Effects of antioxidant vitamins C and E on endothelial function and thrombosis/fibrinolysis system in smokers [J].

Antoniades, C ;

Tousoulis, D ;

Tentolouris, C ;

Toutouza, M ;

Marinou, K ;

Goumas, G ;

Tsioufis, C ;

Toutouzas, P ;

Stefanadis, C .

THROMBOSIS AND HAEMOSTASIS, 2003, 89 (06) :990-995

[4]

5-methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels - Effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling [J].

Antoniades, Charalambos ;

Shirodaria, Cheerag ;

Warrick, Nicholas ;

Cai, Shijie ;

de Bono, Joseph ;

Lee, Justin ;

Leeson, Paul ;

Neubauer, Stefan ;

Ratnatunga, Chandi ;

Pillai, Ravi ;

Refsum, Helga ;

Channon, Keith M. .

CIRCULATION, 2006, 114 (11) :1193-1201

[5]

Homocysteine and coronary atherosclerosis: from folate fortification to the recent clinical trials [J].

Antoniades, Charalambos ;

Antonopoulos, Alexios S. ;

Tousoulis, Dimitris ;

Marinou, Kyriakoula ;

Stefanadis, Christodoulos .

EUROPEAN HEART JOURNAL, 2009, 30 (01) :6-15

[6]

Interactions of platelets, macrophages, and lipoproteins in hypercholesterolemia: Antiatherogenic effects of HMG-CoA reductase inhibitor therapy [J].

Aviram, M ;

Hussein, O ;

Rosenblat, M ;

Schlezinger, S ;

Hayek, T ;

Keidar, S .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1998, 31 (01) :39-45

[7]

Isoprostanes - Prostaglandin-like compounds formed in vivo independently of cyclooxygenase - Use as clinical indicators of oxidant damage [J].

Awad, JA ;

Roberts, JL ;

Burk, RF ;

Morrow, JD .

GASTROENTEROLOGY CLINICS OF NORTH AMERICA, 1996, 25 (02) :409-&

[8]

NEW SIMPLIFIED PROCEDURES FOR THE EXTRACTION AND SIMULTANEOUS HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ANALYSIS OF RETINOL, TOCOPHEROLS AND CAROTENOIDS IN HUMAN SERUM [J].

BARUA, AB ;

KOSTIC, D ;

OLSON, JA .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1993, 617 (02) :257-264

[9]

Wine, research and cardiovascular disease: Instructions for use [J].

Bertelli, Alberto A. E. .

ATHEROSCLEROSIS, 2007, 195 (02) :242-247

[10]

Vitamin-mineral supplementation and the progression of atherosclerosis: a meta-analysis of randomized controlled trials [J].

Bleys, Joachim ;

Miller, Edgar R. ;

Pastor-Barriuso, Roberto ;

Appel, Lawrence J. ;

Guallar, Eliseo .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 2006, 84 (04) :880-887

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