miR-137 effects on gastric carcinogenesis are mediated by targeting Cox-2-activated PI3K/AKT signaling pathway

被引：76

作者：

Cheng, Yan ^{[1
]}

Li, Yang ^{[2
]}

Liu, Dong ^{[1
]}

Zhang, Rong ^{[1
]}

Zhang, Jun ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Affiliated Hosp 2, Sch Med, Dept Digest Dis, Xian 710004, Shaanxi, Peoples R China

[2] Xi An Jiao Tong Univ, Affiliated Hosp 2, Sch Med, Dept Otolaryngol Head & Neck Surg, Xian 710061, Shaanxi, Peoples R China

来源：

FEBS LETTERS | 2014年 / 588卷 / 17期

关键词：

Stomach neoplasm; miR-137; Cyclooxygenase-2; PI3K/AKT signaling pathway; Xenograft tumor; CANCER CELLS; EXPRESSION; COX-2; INHIBITION; MICRORNAS; INVASION; CYCLOOXYGENASE-2; SURVIVAL; PGE(2); CDC42;

D O I：

10.1016/j.febslet.2014.07.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The discovery of microRNAs (miRNAs) provided a new avenue for early diagnosis and treatment of GC. MiR-137 has been reported to be under-expressed and involved in various cell processes. However, the role of miR-137 in GC is less known. In this study, we show that miR-137 is under-expressed in GC and functions as a tumor suppressor through targeting Cyclooxygenase-2 (Cox-2), which subsequently suppresses the activation of PI3K/AKT signaling pathway both in vitro and in vivo. Moreover, restored Cox-2 expression partially abolished the tumor suppressive effects of miR-137 in GC cells, suggesting miR-137 may suppress GC carcinogenesis by targeting Cox-2. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：3274 / 3281

页数：8

共 31 条

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