Plasticity of myeloid-derived suppressor cells in cancer

被引：298

作者：

Tcyganov, Evgenii ^{[1
]}

Mastio, Jerome ^{[1
]}

Chen, Eric ^{[2
]}

Gabrilovich, Dmitry I. ^{[1
,2
]}

机构：

[1] Wistar Inst Anat & Biol, 3601 Spruce St, Philadelphia, PA 19104 USA

[2] Univ Penn, Philadelphia, PA 19104 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2018年 / 51卷

基金：

美国国家卫生研究院;

关键词：

TUMOR-ASSOCIATED MACROPHAGES; INFLAMMATORY MONOCYTES; DENDRITIC CELLS; LY6C(HI) MONOCYTES; M-CSF; DIFFERENTIATION; HETEROGENEITY; RECEPTOR; PROMOTES; FATE;

D O I：

10.1016/j.coi.2018.03.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

In recent years, myeloid-derived suppressor cells (MDSC) have emerged as one of the major inhibitors of immune effector cell function in cancer. MDSC represent a heterogeneous population of largely immature myeloid cells that are characterized by a pathological state of activation and display potent immune suppressive activity. Two major subsets of MDSC have been identified: monocytic (M-MDSC) and polymorphonuclear (PMN-MDSC). PMN-MSDC share phenotypic and morphologic features with neutrophils, whereas M-MDSC are similar to monocytes and are characterized by high plasticity. Differentiation of M-MDSC to macrophages and dendritic cells is shaped by tumor microenvironment. In recent years, the mechanisms of this process start to emerge.

引用

页码：76 / 82

页数：7

共 68 条

[1]

Exogenous lipid uptake induces metabolic and functional reprogramming of tumor-associated myeloid-derived suppressor cells [J].

Al-Khami, Amir A. ;

Zheng, Liqin ;

Del Valle, Luis ;

Hossain, Fokhrul ;

Wyczechowska, Dorota ;

Zabaleta, Jovanny ;

Sanchez, Maria D. ;

Dean, Matthew J. ;

Rodriguez, Paulo C. ;

Ochoa, Augusto C. .

ONCOIMMUNOLOGY, 2017, 6 (10)

[2]

Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis [J].

Arnold, Ludovic ;

Henry, Adeline ;

Poron, Francoise ;

Baba-Amer, Yasmine ;

van Rooijen, Nico ;

Plonquet, Anne ;

Gherardi, Romain K. ;

Chazaud, Benedicte .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (05) :1057-1069

[3]

CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation [J].

Auffray, Cedric ;

Fogg, Darin K. ;

Narni-Mancinelli, Emilie ;

Senechal, Brigitte ;

Trouillet, Celine ;

Saederup, Noah ;

Leemput, Julia ;

Bigot, Karine ;

Campisi, Laura ;

Abitbol, Marc ;

Molina, Thierry ;

Charo, Israel ;

Hume, David A. ;

Cumano, Ana ;

Lauvau, Gregoire ;

Geissmann, Frederic .

JOURNAL OF EXPERIMENTAL MEDICINE, 2009, 206 (03) :595-606

[4]

Systemic Monocytic-MDSCs Are Generated from Monocytes and Correlate with Disease Progression in Breast Cancer Patients [J].

Bergenfelz, Caroline ;

Larsson, Anna-Maria ;

von Stedingk, Kristoffer ;

Gruvberger-Saal, Sofia ;

Aaltonen, Kristina ;

Jansson, Sara ;

Jernstrom, Helena ;

Janols, Helena ;

Wullt, Marlene ;

Bredberg, Anders ;

Ryden, Lisa ;

Leandersson, Karin .

PLOS ONE, 2015, 10 (05)

[5]

Novel insights in the regulation and function of macrophages in the tumor microenvironment [J].

Bolli, Evangelia ;

Movahedi, Kiavash ;

Laoui, Damya ;

Van Ginderachter, Jo A. .

CURRENT OPINION IN ONCOLOGY, 2017, 29 (01) :55-61

[6]

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards [J].

Bronte, Vincenzo ;

Brandau, Sven ;

Chen, Shu-Hsia ;

Colombo, Mario P. ;

Frey, Alan B. ;

Greten, Tim F. ;

Mandruzzato, Susanna ;

Murray, Peter J. ;

Ochoa, Augusto ;

Ostrand-Rosenberg, Suzanne ;

Rodriguez, Paulo C. ;

Sica, Antonio ;

Umansky, Viktor ;

Vonderheide, Robert H. ;

Gabrilovich, Dmitry I. .

NATURE COMMUNICATIONS, 2016, 7

[7]

Impeding Macrophage Entry into Hypoxic Tumor Areas by Sema3A/Nrp1 Signaling Blockade Inhibits Angiogenesis and Restores Antitumor Immunity [J].

Casazza, Andrea ;

Laoui, Damya ;

Wenes, Mathias ;

Rizzolio, Sabrina ;

Bassani, Nicklas ;

Mambretti, Marco ;

Deschoemaeker, Sofie ;

Van Ginderachter, Jo A. ;

Tamagnone, Luca ;

Mazzone, Massimiliano .

CANCER CELL, 2013, 24 (06) :695-709

[8]

Lectin-type oxidized LDL receptor-1 distinguishes population of human polymorphonuclear myeloid-derived suppressor cells in cancer patients [J].

Condamine, Thomas ;

Dominguez, George A. ;

Youn, Je-In ;

Kossenkov, Andrew V. ;

Mony, Sridevi ;

Alicea-Torres, Kevin ;

Tcyganov, Evgenii ;

Hashimoto, Ayumi ;

Nefedova, Yulia ;

Lin, Cindy ;

Partlova, Simona ;

Garfall, Alfred ;

Vogl, Dan T. ;

Xu, Xiaowei ;

Knight, Stella C. ;

Malietzis, George ;

Lee, Gui Han ;

Eruslanov, Evgeniy ;

Albelda, Steven M. ;

Wang, Xianwei ;

Mehta, Jawahar L. ;

Bewtra, Meenakshi ;

Rustgi, Anil ;

Hockstein, Neil ;

Witt, Robert ;

Masters, Gregory ;

Nam, Brian ;

Smirnov, Denis ;

Sepulveda, Manuel A. ;

Gabrilovich, Dmitry I. .

SCIENCE IMMUNOLOGY, 2016, 1 (02)

[9]

Transcriptional regulation of myeloid-derived suppressor cells [J].

Condamine, Thomas ;

Mastio, Jerome ;

Gabrilovich, Dmitry I. .

JOURNAL OF LEUKOCYTE BIOLOGY, 2015, 98 (06) :913-922

[10]

Regulation of Tumor Metastasis by Myeloid-Derived Suppressor Cells [J].

Condamine, Thomas ;

Ramachandran, Indu ;

Youn, Je-In ;

Gabrilovich, Dmitry I. .

ANNUAL REVIEW OF MEDICINE, VOL 66, 2015, 66 :97-110

← 1 2 3 4 5 6 7 →