Genetic instability and darwinian selection in tumours

被引：67

作者：

Cahill, DP ^{[1
]}

Kinzler, KW

Vogelstein, B

Lengauer, C

机构：

[1] Johns Hopkins Univ, Sch Med, Program Human Genet, Baltimore, MD 21231 USA

[2] Johns Hopkins Univ, Sch Med, Johns Hopkins Oncol Ctr, Baltimore, MD 21231 USA

[3] Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Baltimore, MD 21231 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1999年 / 24卷 / 12期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0968-0004(99)01466-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genetic instability has long been hypothesized to be a cardinal feature of cancer. Recent work has strengthened the proposal that mutational alterations conferring instability occur early during tumour formation. The ensuing genetic instability drives tumour progression by generating mutations in oncogenes and tumour-suppressor genes. These mutant genes provide cancer cells with a selective growth advantage, thereby Leading to the clonal outgrowth of a tumour. Here, we discuss the role of genetic instability in tumour formation and outline future work necessary to substantiate the genetic instability hypothesis.

引用

页码：M57 / M60

页数：4

共 46 条

[21] Lessons from hereditary colorectal cancer [J].

Kinzler, KW ;

Vogelstein, B .

CELL, 1996, 87 (02) :159-170

[22]

KOI M, 1994, CANCER RES, V54, P4308

[23] Genetic instability in colorectal cancers [J].

Lengauer, C ;

Kinzler, KW ;

Vogelstein, B .

NATURE, 1997, 386 (6625) :623-627

[24] Genetic instabilities in human cancers [J].

Lengauer, C ;

Kinzler, KW ;

Vogelstein, B .

NATURE, 1998, 396 (6712) :643-649

[25]

LEVY DB, 1994, CANCER RES, V54, P5953

[26] FEEDBACK-CONTROL OF MITOSIS IN BUDDING YEAST [J].

LI, R ;

MURRAY, AW .

CELL, 1991, 66 (03) :519-531

[27] ALTERED CELL-CYCLE ARREST AND GENE AMPLIFICATION POTENTIAL ACCOMPANY LOSS OF WILD-TYPE P53 [J].

LIVINGSTONE, LR ;

WHITE, A ;

SPROUSE, J ;

LIVANOS, E ;

JACKS, T ;

TISTY, TD .

CELL, 1992, 70 (06) :923-935

[28]

LOEB LA, 1991, CANCER RES, V51, P3075

[29]

LOEB LA, 1974, CANCER RES, V34, P2311

[30] THE MUTATIONAL MELTDOWN IN ASEXUAL POPULATIONS [J].

LYNCH, M ;

BURGER, R ;

BUTCHER, D ;

GABRIEL, W .

JOURNAL OF HEREDITY, 1993, 84 (05) :339-344

← 1 2 3 4 5 →