Genetic instability and darwinian selection in tumours

被引：67

作者：

Cahill, DP ^{[1
]}

Kinzler, KW

Vogelstein, B

Lengauer, C

机构：

[1] Johns Hopkins Univ, Sch Med, Program Human Genet, Baltimore, MD 21231 USA

[2] Johns Hopkins Univ, Sch Med, Johns Hopkins Oncol Ctr, Baltimore, MD 21231 USA

[3] Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Baltimore, MD 21231 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1999年 / 24卷 / 12期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0968-0004(99)01466-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genetic instability has long been hypothesized to be a cardinal feature of cancer. Recent work has strengthened the proposal that mutational alterations conferring instability occur early during tumour formation. The ensuing genetic instability drives tumour progression by generating mutations in oncogenes and tumour-suppressor genes. These mutant genes provide cancer cells with a selective growth advantage, thereby Leading to the clonal outgrowth of a tumour. Here, we discuss the role of genetic instability in tumour formation and outline future work necessary to substantiate the genetic instability hypothesis.

引用

页码：M57 / M60

页数：4

共 46 条

[31] Proliferation of mutators in a cell population [J].

Mao, EF ;

Lane, L ;

Lee, J ;

Miller, JH .

JOURNAL OF BACTERIOLOGY, 1997, 179 (02) :417-422

[32]

McCormick F, 1999, TRENDS CELL BIOL, V9, pM53, DOI 10.1016/S0962-8924(99)01668-2

[33]

Miller JH, 1996, CANCER SURV, V28, P141

[34] Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC [J].

Morin, PJ ;

Sparks, AB ;

Korinek, V ;

Barker, N ;

Clevers, H ;

Vogelstein, B ;

Kinzler, KW .

SCIENCE, 1997, 275 (5307) :1787-1790

[35] MUTATIONS OF CHROMOSOME-5Q21 GENES IN FAP AND COLORECTAL-CANCER PATIENTS [J].

NISHISHO, I ;

NAKAMURA, Y ;

MIYOSHI, Y ;

MIKI, Y ;

ANDO, H ;

HORII, A ;

KOYAMA, K ;

UTSUNOMIYA, J ;

BABA, S ;

HEDGE, P ;

MARKHAM, A ;

KRUSH, AJ ;

PETERSEN, G ;

HAMILTON, SR ;

NILBERT, MC ;

LEVY, DB ;

BRYAN, TM ;

PREISINGER, AC ;

SMITH, KJ ;

SU, LK ;

KINZLER, KW ;

VOGELSTEIN, B .

SCIENCE, 1991, 253 (5020) :665-669

[36] CLONAL EVOLUTION OF TUMOR-CELL POPULATIONS [J].

NOWELL, PC .

SCIENCE, 1976, 194 (4260) :23-28

[37] HYPERMUTABILITY AND MISMATCH REPAIR DEFICIENCY IN RER+ TUMOR-CELLS [J].

PARSONS, R ;

LI, GM ;

LONGLEY, MJ ;

FANG, WH ;

PAPADOPOULOS, N ;

JEN, J ;

DELACHAPELLE, A ;

KINZLER, KW ;

VOGELSTEIN, B ;

MODRICH, P .

CELL, 1993, 75 (06) :1227-1236

[38]

Peltomaki P, 1997, ADV CANCER RES, V71, P93, DOI 10.1016/S0065-230X(08)60097-4

[39] How aneuploidy affects metabolic control and causes cancer [J].

Rasnick, D ;

Duesberg, PH .

BIOCHEMICAL JOURNAL, 1999, 340 :621-630

[40]

Reed John C., 1999, Current Opinion in Oncology, V11, P68, DOI 10.1097/00001622-199901000-00014

← 1 2 3 4 5 →