The immune landscape of human tumors Implications for cancer immunotherapy

被引：103

作者：

Bindea, Gabriela

Mlecnik, Bernhard

Angell, Helen K. ^{[1
]}

Galon, Jerome ^{[1
]}

机构：

[1] AstraZeneca, Mol Pathol Grp, Alderley Pk, Cheshire, England

来源：

ONCOIMMUNOLOGY | 2014年 / 3卷 / 01期

关键词：

immunoscore; immune landscape; cancer; prognosis; bioinformatics; CELLS;

D O I：

10.4161/onci.27456

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Understanding the spontaneous immune response of cancer patients is critical for the design of efficient anticancer immunotherapies. The power of integrative tumor immunology approaches allowed for a comprehensive view of the immune system evolution in the course of tumor progression and recurrence. We have demonstrated that tumor-infiltrating immune cells are spatiotemporally regulated, a finding that has profound implications for the development of efficient anticancer immunotherapies.

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