Intricate knots in proteins: Function and evolution

被引：288

作者：

Virnau, Peter ^{[1
]}

Mirny, Leonid A.

Kardar, Mehran

机构：

[1] MIT, Dept Phys, Cambridge, MA 02139 USA

[2] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA

来源：

PLOS COMPUTATIONAL BIOLOGY | 2006年 / 2卷 / 09期

关键词：

D O I：

10.1371/journal.pcbi.0020122

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Our investigation of knotted structures in the Protein Data Bank reveals the most complicated knot discovered to date. We suggest that the occurrence of this knot in a human ubiquitin hydrolase might be related to the role of the enzyme in protein degradation. While knots are usually preserved among homologues, we also identify an exception in a transcarbamylase. This allows us to exemplify the function of knots in proteins and to suggest how they may have been created.

引用

收藏

页码：1074 / 1079

页数：6

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