Involvement of 5-hydroxytryptamine neuronal system in Δ9-tetrahydrocannabinol-induced impairment of spatial memory

被引:65
作者
Egashira, N
Mishima, K
Katsurabayashi, S
Yoshitake, T
Matsumoto, Y
Ishida, J
Yamaguchi, M
Iwasaki, K
Fujiwara, M [1 ]
机构
[1] Fukuoka Univ, Fac Pharmaceut Sci, Dept Physiol & Pharmacol, Fukuoka 8140180, Japan
[2] Fukuoka Univ, Fac Pharmaceut Sci, Dept Analyt Chem, Fukuoka 8140180, Japan
[3] Chem Inspect & Testing Inst, Chem Biotesting Ctr, Oita, Japan
[4] Kyushu Womens Jr Coll, Sch Nursing, Kitakyushu, Fukuoka 8078586, Japan
关键词
Delta(9)-tetrahydrocannabinol; 5-HT; (5-hydroxytryptamine; serotonin); hippocampus; spatial memory; DOI (I -(2,5-dimethoxy 4-iodophenyl)-2-amino; propane);
D O I
10.1016/S0014-2999(02)01755-7
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The present study investigated the involvement of the serotonin (5-hydroxytryptamine, 5-HT) neuronal system in the Delta(9)-tetrahydrocannabinol-induced impairment of spatial memory in the eight-ann radial maze in rats. Delta(9)-Tetrahydrocannabinol (6 mg/kg, i.p.), which impairs spatial memory, significantly increased the 5-HT content in the ventral hippocampus. A microdialysis study showed that Delta(9)-tetrahydrocannabinol (6 mg/kg, i.p.) decreased 5-HT release in the ventral hippocampus. The 5-HT precursor, 5-hydroxy-L-tryptophan (5-HTP 50 mg/kg, i.p.), the 5-HT re-uptake inhibitor, clomipramine (0.01 and 0.1 mg/kg, i.p.), the 5-HT receptor agonist, 5-methoxy-N,N-dimethyltryptamine (5-MeODMT; 0.01 and 0.03 mg/kg, i.p.), and the 5-HT2 receptor agonist, 1-(2,5-dimethoxy 4-iodophenyl)-2-amino propane (DOI; 10 mug/kg, i.p.), significantly attenuated the Delta(9)-tetrahydrocannabinol-induced impairment of spatial memory. These results suggest that the 5-HT neuronal system may be involved in the Delta(9)-tetrahydrocannabinol-induced impairment of spatial memory. (C) 2002 Elsevier Science B.V All rights reserved.
引用
收藏
页码:221 / 229
页数:9
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