Nerve growth factor treatment prevents dendritic atrophy and promotes recovery of function after cortical injury

被引：88

作者：

Kolb, B ^{[1
]}

Cote, S ^{[1
]}

RibeiroDaSilva, A ^{[1
]}

Cuello, AC ^{[1
]}

机构：

[1] MCGILL UNIV,DEPT PHARMACOL & THERAPEUT,MONTREAL,PQ,CANADA

来源：

NEUROSCIENCE | 1997年 / 76卷 / 04期

基金：

美国国家卫生研究院; 加拿大自然科学与工程研究理事会;

关键词：

NGF; functional recovery; cortex; dendritic arborization; synaptogenesis;

D O I：

10.1016/S0306-4522(96)00448-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study examined the behavioural and anatomical effects of intraventricular injections of nerve growth factor in rats with unilateral damage that included Zilles' areas Frl, FL, HL, Par1 and the anterior portion of Oc2. Nerve growth factor-treated lesion rats showed attenuation of behavioural symptoms in measures of forelimb function (Whishaw reaching task) and hindlimb function (beam traversing task) as well as a measure of spatial navigation (Morris water task). Analysis of dendritic arborization using a modified Golgi-Cox procedure also showed a complete reversal of lesion-induced atrophy of dendritic fields in pyramidal neurons in motor (Zilles' Fr2) and cingulate (Zilles' Cg1) cortex. In addition, there was a reversal of a lesion-induced reduction in spine density. These results demonstrate that nerve growth factor treatment can facilitate functional recovery from cortical injury. This recovery map be mediated by a reorganization of intrinsic cortical circuitry that is reflected in changes in dendritic arborization and spine density of pyramidal neurons. Copyright (C) 1996 IBRO. Published by Elsevier Science Ltd.

引用

页码：1139 / 1151

页数：13

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