Hidden biosynthetic treasures brought to light

被引：107

作者：

Hertweck, Christian ^{[1
,2
]}

机构：

[1] Hans Knoll Inst Jena, Leibniz Inst Nat Prod Res & Infect Biol, Dept Biomol Chem, Jena, Germany

[2] Univ Jena, Jena, Germany

来源：

NATURE CHEMICAL BIOLOGY | 2009年 / 5卷 / 07期

关键词：

NATURAL-PRODUCTS; GENE-CLUSTER; CHEMICAL DIVERSITY; BACTERIAL SYMBIONT; RNA-POLYMERASE; DISCOVERY; ASPERGILLUS; ACTIVATION; MUTATIONS; PATHWAY;

D O I：

10.1038/nchembio0709-450

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Microorganisms are a major source of new therapeutics. However, the discovery and sustainable production of these compounds are often hampered owing to limited access to biosynthetic genes or products. Recent studies provide new approaches for targeting biosynthesis genes in the metagenome of complex microbial assemblages and for inducing the expression of otherwise silent biosynthesis genes.

引用

收藏

页码：450 / 452

页数：3

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