InterProScan 5: genome-scale protein function classification

被引：5891

作者：

Jones, Philip ^{[1
,2
]}

Binns, David ^{[1
]}

Chang, Hsin-Yu ^{[1
]}

Fraser, Matthew ^{[1
]}

Li, Weizhong ^{[1
]}

McAnulla, Craig ^{[1
]}

McWilliam, Hamish ^{[1
]}

Maslen, John ^{[1
,2
]}

Mitchell, Alex ^{[1
]}

Nuka, Gift ^{[1
]}

Pesseat, Sebastien ^{[1
]}

Quinn, Antony F. ^{[1
]}

Sangrador-Vegas, Amaia ^{[1
]}

Scheremetjew, Maxim ^{[1
]}

Yong, Siew-Yit ^{[1
]}

Lopez, Rodrigo ^{[1
]}

Hunter, Sarah ^{[1
]}

机构：

[1] European Bioinformat Inst EMBL EBI, European Mol Biol Lab, Hinxton CB10 1SD, England

[2] Wellcome Trust Sanger Inst, Hinxton CB10 1SA, England

来源：

BIOINFORMATICS | 2014年 / 30卷 / 09期

基金：

英国生物技术与生命科学研究理事会;

关键词：

FAMILY CLASSIFICATION; ANNOTATION; TOPOLOGY;

D O I：

10.1093/bioinformatics/btu031

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Motivation: Robust large-scale sequence analysis is a major challenge in modern genomic science, where biologists are frequently trying to characterize many millions of sequences. Here, we describe a new Java-based architecture for the widely used protein function prediction software package InterProScan. Developments include improvements and additions to the outputs of the software and the complete reimplementation of the software framework, resulting in a flexible and stable system that is able to use both multiprocessor machines and/or conventional clusters to achieve scalable distributed data analysis. InterProScan is freely available for download from the EMBl-EBI FTP site and the open source code is hosted at Google Code.

引用

页码：1236 / 1240

页数：5

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