Nickel-Catalyzed [4+2] Cycloaddition of Enones with Alkynes

被引：40

作者：

Koyama, Ichiro ^{[1
]}

Kurahashi, Takuya ^{[1
]}

Matsubara, Seijiro ^{[1
]}

机构：

[1] Kyoto Univ, Dept Chem Mat, Grad Sch Engn, Kyoto 6158510, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 04期

关键词：

DIELS-ALDER REACTIONS; INVERSE-ELECTRON-DEMAND; OXIDATIVE CYCLIZATION; KEY INTERMEDIATE; ISOCYANATES; COUPLINGS; ALDEHYDES; DIYNES; <2&2&2'>-CYCLOADDITION; ETA(2)-ALKENE;

D O I：

10.1021/ja807952r

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A nickel-catalyzed [4 + 2] cycloaddition reaction has been developed where enones react with alkynes to afford polysubstituted pyrans. A mechanistic rationale is proposed, implying oxa-nickela cycle formation by oxidative cyclization of nickel to enone, followed by alkyne insertion.

引用

页码：1350 / +

页数：3

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