Nickel-Catalyzed [4+2] Cycloaddition of Enones with Alkynes

被引:40
作者
Koyama, Ichiro [1 ]
Kurahashi, Takuya [1 ]
Matsubara, Seijiro [1 ]
机构
[1] Kyoto Univ, Dept Chem Mat, Grad Sch Engn, Kyoto 6158510, Japan
关键词
DIELS-ALDER REACTIONS; INVERSE-ELECTRON-DEMAND; OXIDATIVE CYCLIZATION; KEY INTERMEDIATE; ISOCYANATES; COUPLINGS; ALDEHYDES; DIYNES; <2&2&2'>-CYCLOADDITION; ETA(2)-ALKENE;
D O I
10.1021/ja807952r
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A nickel-catalyzed [4 + 2] cycloaddition reaction has been developed where enones react with alkynes to afford polysubstituted pyrans. A mechanistic rationale is proposed, implying oxa-nickela cycle formation by oxidative cyclization of nickel to enone, followed by alkyne insertion.
引用
收藏
页码:1350 / +
页数:3
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