Nickel-catalyzed cycloaddition of alkynes and isocyanates

被引：143

作者：

Duong, HA ^{[1
]}

Cross, MJ ^{[1
]}

Louie, J ^{[1
]}

机构：

[1] Univ Utah, Dept Chem, Salt Lake City, UT 84112 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 37期

关键词：

D O I：

10.1021/ja046477i

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A mild and general route for preparing 2-pyridones from isocyanates and diynes is described. Ni imidazolyidene complexes were used to mediate cyclizations between both internal and terminal diynes with aryl and alkyl isocyanates. In addition, the efficacy of this protocol allows for the preparation of a fused seven-membered pyridone and for three component cyclizations. Copyright © 2003 American Chemical Society.

引用

页码：11438 / 11439

页数：2

共 21 条

[1] Baxendale IR, 2002, ANGEW CHEM INT EDIT, V41, P2194, DOI 10.1002/1521-3773(20020617)41:12<2194::AID-ANIE2194>3.0.CO
[2] 2-4
[3] 8-methyl-pyridoxatin:: A novel N-hydroxy pyridone from fungus OS-F61800 that induces erythropoietin in human cells
Cai, P
Smith, D
Cunningham, B
Brown-Shimer, S
Katz, B
Pearce, C
Venables, D
Houck, D
[J]. JOURNAL OF NATURAL PRODUCTS, 1999, 62 (02): : 397 - 399
[4] THE PREPARATION OF 2(1H)-PYRIDINONES AND 2,3-DIHYDRO-5(1H)-INDOLIZINONES VIA TRANSITION-METAL MEDIATED COCYCLIZATION OF ALKYNES AND ISOCYANATES - A NOVEL CONSTRUCTION OF THE ANTITUMOR AGENT CAMPTOTHECIN
EARL, RA
VOLLHARDT, KPC
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1984, 49 (25) : 4786 - 4800
[5] Grotjahn D. B, 1995, COMPREHENSIVE ORGANO, V12, P741
[6] HOBERG H, 1982, SYNTHESIS-STUTTGART, P324
[7] MODEL COMPLEX OF NICKEL FOR THE C-C BONDING OF ALKYNES WITH ISOCYANATES
HOBERG, H
OSTER, BW
[J]. JOURNAL OF ORGANOMETALLIC CHEMISTRY, 1982, 234 (02) : C35 - C38
[8] NICKEL COMPOUNDS AS INTERMEDIATE COMPLEXES OF [2+2+2']-CYCLOADDITION OF ALKYNES WITH ISOCYANATES OF 2-PYRIDONES
HOBERG, H
OSTER, BW
[J]. JOURNAL OF ORGANOMETALLIC CHEMISTRY, 1983, 252 (03) : 359 - 364
[9] Hong P., 1977, TETRAHEDRON LETT, P1333
[10] Transfer hydrogenation of imines catalyzed by a nickel(0)/NHC complex
Kuhl, S
Schneider, R
Fort, Y
[J]. ORGANOMETALLICS, 2003, 22 (21) : 4184 - 4186

← 1 2 3 →