A Review of Organic and Inorganic Biomaterials for Neural Interfaces

被引:452
作者
Fattahi, Pouria [3 ,4 ]
Yang, Guang [2 ]
Kim, Gloria [2 ]
Abidian, Mohammad Reza [1 ]
机构
[1] Penn State Univ, Dept Biomed Engn, Mat Sci & Engn Dept, Chem Engn Dept,Mat Res Inst,Huck Inst Life Sci, University Pk, PA 16802 USA
[2] Penn State Univ, Dept Biomed Engn, University Pk, PA 16802 USA
[3] Penn State Univ, Dept Biomed Engn, University Pk, PA 16802 USA
[4] Penn State Univ, Dept Chem Engn, University Pk, PA 16802 USA
关键词
biomaterials; conducting polymers; carbon nanotubes; graphene; nanowires; WALLED CARBON NANOTUBES; NERVE GROWTH-FACTOR; CONDUCTING-POLYMER NANOTUBES; ELECTROCHEMICALLY CONTROLLED-RELEASE; SILICON MICROELECTRODE ARRAYS; GRAPHENE-MODIFIED ELECTRODE; BRAIN-MACHINE INTERFACES; IN-VIVO; NEURITE OUTGROWTH; MULTIELECTRODE ARRAY;
D O I
10.1002/adma.201304496
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Recent advances in nanotechnology have generated wide interest in applying nanomaterials for neural prostheses. An ideal neural interface should create seamless integration into the nervous system and performs reliably for long periods of time. As a result, many nanoscale materials not originally developed for neural interfaces become attractive candidates to detect neural signals and stimulate neurons. In this comprehensive review, an overview of state-of-the-art microelectrode technologies provided first, with focus on the material properties of these microdevices. The advancements in electroactive nanomaterials are then reviewed, including conducting polymers, carbon nanotubes, graphene, silicon nanowires, and hybrid organic-inorganic nanomaterials, for neural recording, stimulation, and growth. Finally, technical and scientific challenges are discussed regarding biocompatibility, mechanical mismatch, and electrical properties faced by these nanomaterials for the development of long-lasting functional neural interfaces.
引用
收藏
页码:1846 / 1885
页数:40
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