Evidence for recombination of live, attenuated immunodeficiency virus vaccine with challenge virus to a more virulent strain

被引:64
作者
Gundlach, BR
Lewis, MG
Sopper, S
Schnell, T
Sodroski, J
Stahl-Hennig, C
Überla, K
机构
[1] Univ Leipzig, Inst Virol, D-04103 Leipzig, Germany
[2] Univ Erlangen Nurnberg, Inst Virol, Erlangen, Germany
[3] Univ Wurzburg, Inst Virol & Immunobiol, D-8700 Wurzburg, Germany
[4] Deutsch Primatenzentrum, Gottingen, Germany
[5] Henry M Jackson Fdn, Rockville, MD USA
[6] Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA
关键词
D O I
10.1128/JVI.74.8.3537-3542.2000
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Live, attenuated immunodeficiency virus vaccines, such as nef deletion mutants, are the most effective vaccines tested in the simian immunodeficiency virus (SIV) macaque model. In two independent studies designed to determine the breadth of protection induced by live, attenuated SN vaccines, we noticed that three of the vaccinated macaques developed higher set point viral load levels than unvaccinated control monkeys, Two of these vaccinated monkeys developed AIDS, while the control monkeys infected in parallel remained asymptomatic. Concomitant with an increase in viral load, a recombinant of the vaccine virus and the challenge virus could be detected. Therefore, the emergence of more-virulent recombinants of live, attenuated immunodeficiency viruses and less-aggressive wild-type viruses seems to be an additional risk of live, attenuated immunodeficiency virus vaccines.
引用
收藏
页码:3537 / 3542
页数:6
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