Efficient microwave assisted access to chiral O-(α-protected-aminoacyl)steroids

被引：32

作者：

Katritzky, Alan R. ^{[1
]}

Angrish, Parul ^{[1
]}

机构：

[1] Univ Florida, Dept Chem, Ctr Heterocycl Ctds, Gainesville, FL 32611 USA

来源：

STEROIDS | 2006年 / 71卷 / 08期

关键词：

N-(Z-alpha-aminoacyl)benzotriazole; O(alpha-protected-aminoacyl)steroid; O-acylation; chirality; microwave;

D O I：

10.1016/j.steroids.2006.04.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chiral O-(alpha-protected-amino acyl)steroids 4a-f, 6a-b, 8 and 4a+4d and O-(alpha-protected-dipeptidoyl) steroids 12a,b are conveniently prepared under microwave irradiation in isolated yields of 65-96%, with complete chirality retention. The reaction utilized readily available N-(Z-alpha-aminoacyl)benzotriazoles 2a-f and Z-dipeptidoylbenzotriazole 11, with naturally occurring steroidal alcohols 3,5,7,9. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：660 / 669

页数：10

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