Strategies for improving fermentation medium performance: a review

被引:248
作者
Kennedy, M [1 ]
Krouse, D [1 ]
机构
[1] Ind Res Ltd, Lower Hutt, New Zealand
关键词
medium design; medium optimization; fermentation; gamma-linolenic acid; neural networks; fuzzy logic; genetic algorithms;
D O I
10.1038/sj.jim.2900755
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Many techniques are available in the fermentation medium designer's toolbox (borrowing, component swapping, biological mimicry, one-at-a-time, statistical and mathematical techniques-experimental design and optimization, artificial neural networks, fuzzy logic, genetic algorithms, continuous fermentation, pulsed batch and stoichiometric analysis). Each technique has advantages and disadvantages, and situations where they are best applied. No one 'magic bullet' technique exists for all situations. However, considerable advantage can be gained by logical application of the techniques, combined with good experimental design.
引用
收藏
页码:456 / 475
页数:20
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