Expanded-spectrum cephalosporin resistance in non-typhoid Salmonella

被引：94

作者：

Miriagou, V

Tassios, PT

Legakis, NJ

Tzouvelekis, LS ^{[1
]}

机构：

[1] Hellenic Pasteur Inst, Bacteriol Lab, Athens, Greece

[2] Univ Athens, Sch Med, Dept Microbiol, Athens 11527, Greece

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2004年 / 23卷 / 06期

关键词：

Salmonella; resistance; cephalosporin;

D O I：

10.1016/j.ijantimicag.2004.03.006

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Expanded-spectrum cephalosporins (ESCs) such as ceftriaxone, together with fluorinated quinolones, are the choice antibiotics in the treatment of invasive salmonella infections. Resistance to ESCs among non-typhoid salmonella has been recognised since the late 1980s. Currently, ESC-resistant salmonella strains are reported world-wide and in some areas their incidence is significant. Resistance is mainly due to acquisition of multi-resistant plasmids encoding a variety of extended- spectrum and AmpC-type beta-lactamases. The origins of ESC-resistant salmonellae are diverse. Exchange of resistance determinants between salmonellae and nosocomial enterobacteria seems to be frequent, at least in developing countries. Also, the use of newer beta-lactams in animal husbandry and veterinary medicine may have facilitated the spread of ESC-resistant salmonella strains in livestock. (C) 2004 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

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页码：547 / 555

页数：9

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