Epidermal stem cells: an update

被引：147

作者：

Watt, Fiona M.

Lo Celso, Cristina

Silva-Vargas, Violeta

机构：

[1] Canc Res UK London Res Inst, London WC2A 3PX, England

[2] Massachusetts Gen Hosp, Ctr Regenerat Med, Boston, MA 02114 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2006年 / 16卷 / 05期

关键词：

D O I：

10.1016/j.gde.2006.08.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The mammalian epidermis is a highly accessible tissue in which to study the properties of adult stem cells. Global gene expression profiling has revealed new markers and regulators of the stem cell compartment. Although stem cells have the potential to differentiate into multiple lineages, their progeny follow a more restricted number of lineages in undamaged epidermis as a result of local microenvironmental cues. The response of the epidermis to a particular signal depends on signal strength and duration. Recent advances in the field have led to elucidation of the mechanisms by which stem cells are maintained and the pathways that interact with Wnt signalling to specify lineage choice as cells leave the stem cell compartment. This work has also yielded new insights into skin tumour development.

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收藏

页码：518 / 524

页数：7

相关论文

共 42 条

[1] The hair cycle [J].

Alonso, L ;

Fuchs, E .

JOURNAL OF CELL SCIENCE, 2006, 119 (03) :391-393

[2] Stem cell depletion through epidermal deletion of Rac1 [J].

Benitah, SA ;

Frye, M ;

Glogauer, M ;

Watt, FM .

SCIENCE, 2005, 309 (5736) :933-935

[3] Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche [J].

Blanpain, C ;

Lowry, WE ;

Geoghegan, A ;

Polak, L ;

Fuchs, E .

CELL, 2004, 118 (05) :635-648

[4] Essential role of BCL9-2 in the switch between β-catenin's adhesive and transcriptional functions [J].

Brembeck, FH ;

Schwarz-Romond, T ;

Bakkers, J ;

Wilhelm, S ;

Hammerschmidt, M ;

Birchmeier, W .

GENES & DEVELOPMENT, 2004, 18 (18) :2225-2230

[5] Long-term renewal of hair follicles from clonogenic multipotent stem cells [J].

Claudinot, S ;

Nicolas, M ;

Oshima, H ;

Rochat, A ;

Barrandon, Y .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (41) :14677-14682

[6] Gene expression profiling gets to the root of human hair follicle stem cells [J].

Cotsarelis, G .

JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (01) :19-22

[7] P21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation [J].

Devgan, V ;

Mammucari, C ;

Millar, SE ;

Brisken, C ;

Dotto, GP .

GENES & DEVELOPMENT, 2005, 19 (12) :1485-1495

[8] Effects of telomerase and telomere length on epidermal stem cell behavior [J].

Flores, I ;

Cayuela, ML ;

Blasco, MA .

SCIENCE, 2005, 309 (5738) :1253-1256

[9] The RNA methyltransferase Misu (NSun2) mediates Myc-induced proliferation and is upregulated in tumors [J].

Frye, Michaela ;

Watt, Fiona M. .

CURRENT BIOLOGY, 2006, 16 (10) :971-981

[10] Socializing with the neighbors: Stem cells and their niche [J].

Fuchs, E ;

Tumbar, T ;

Guasch, G .

CELL, 2004, 116 (06) :769-778

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