Interleukin 35 (IL-35) and IL-37: Intestinal and peripheral expression by T and B regulatory cells in patients with Inflammatory Bowel Disease

被引：113

作者：

Fonseca-Camarillo, Gabriela ^{[1
]}

Furuzawa-Carballeda, Janette ^{[2
]}

Yamamoto-Furusho, Jesus K. ^{[1
]}

机构：

[1] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Inflammatory Bowel Dis Clin, Dept Gastroenterol, Mexico City 14000, DF, Mexico

[2] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Immunol & Rheumatol, Mexico City 14000, DF, Mexico

来源：

CYTOKINE | 2015年 / 75卷 / 02期

关键词：

Interleukin (IL)-35; IL-37; IDO; Crohn's disease; Ulcerative colitis; INDUCED ARTHRITIS; AUTOIMMUNE;

D O I：

10.1016/j.cyto.2015.04.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The aim of the study was to characterize and to quantify peripheral and tissue. IL-35- and IL-37- producing cells in Inflammatory Bowel Disease (IBD) patients. We studied a total of 38 active UC, 31 inactive UC, 17 active CD, and 13 inactive CD and 50 non-inflamed tissues as control group. Gene expression was measured by real time polymerase chain reaction (RT-PCR) and protein expression was evaluated in tissue by immunohistochemistry and in peripheral blood mononuclear cells by flow cytometry. Higher levels of IL-35 was produced by intestinal regulatory B cells and circulating regulatory CD+ and CD8(+) T cells in active vs. inactive disease or healthy donors (P < 0.05). The IL-37 was conspicuously synthesized by circulating B cells, active natural killer cells and monocytes. These results suggest that down-regulation of inflammation in active IBD patients might be based on the increased expression of IL-35 and IL-37. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：389 / 402

页数：14

共 24 条

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[2]

Interleukin-37 is increased in ankylosing spondylitis patients and associated with disease activity [J].