Anti-histaminic activity of bromopyrrole alkaloids isolated from Caribbean Agelas sponges

被引：75

作者：

Cafieri, F

Carnuccio, R

Fattorusso, E

TaglialatelaScafati, O

Vallefuoco, T

机构：

[1] DIPARTIMENTO CHIM SOSTANZE NAT, I-80131 NAPLES, ITALY

[2] DIPARTIMENTO FARMACOL SPERIMENTALE, I-80131 NAPLES, ITALY

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 17期

关键词：

D O I：

10.1016/S0960-894X(97)00415-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four Caribbean Agelas sponges (A. clathrodes, A. conifera, A. dispar. A. longissima) have been investigated for the alkaloid composition. Along with a series of known bromopyrrole alkaloids, two related novel compounds of this class, dispacamides C (7) and D (8), were found and their structures determined with spectroscopic methods. All the isolated Agelas bromopyrrole alkaloids have been evaluated for the antihistaminic activity on the guinea pig ileum. (C) 1997 Elsevier Science Ltd.

引用

页码：2283 / 2288

页数：6

共 12 条

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