Effects of cantharidinimides on human carcinoma cells

被引:35
作者
Lin, LH
Huang, HS
Lin, CC
Lee, LW
Lin, PY
机构
[1] Taipei Med Univ, Sch Pharm, Dept Med Chem, Taipei 110, Taiwan
[2] Natl Def Med Ctr, Sch Pharm, Taipei, Taiwan
[3] Taipei Med Univ, Sch Med, Dept Microbiol & Immunol, Taipei 110, Taiwan
关键词
cantharidin; cantharidinimidel; HepG2; HL-60;
D O I
10.1248/cpb.52.855
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Modification of the cantharidinimide structure led to the discovery of a novel class of antitumor compounds. These cantharidinimide derivatives containing aliphartic, aryl, and pyridyl groups showed some effect in vitro against HepG2 and HL-60 cells.
引用
收藏
页码:855 / 857
页数:3
相关论文
共 15 条
[1]   CANTHARIDIN PRODUCTION IN A BLISTER BEETLE [J].
CARREL, JE ;
MCCAIREL, MH ;
SLAGLE, AJ ;
DOOM, JP ;
BRILL, J ;
MCCORMICK, JP .
EXPERIENTIA, 1993, 49 (02) :171-174
[2]  
Decker R.H., 1963, J INVEST DERMATOL, V42, P465, DOI DOI 10.1038/JID.1964.99
[3]  
Fillmore K., 1966, J INVEST DERMATOL, V47, P606
[4]   CANTHARIDIN POISONING ASSOCIATED WITH SPECIFIC BINDING-SITE IN LIVER [J].
GRAZIANO, MJ ;
WATERHOUSE, AL ;
CASIDA, JE .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 149 (01) :79-85
[5]   CANTHARIDIN, ANOTHER NATURAL TOXIN THAT INHIBITS THE ACTIVITY OF SERINE THREONINE PROTEIN PHOSPHATASES TYPE-1 AND TYPE-2A [J].
HONKANEN, RE .
FEBS LETTERS, 1993, 330 (03) :283-286
[6]   CANTHARIDIN-BINDING PROTEIN - IDENTIFICATION AS PROTEIN PHOSPHATASE-2A [J].
LI, YM ;
CASIDA, JE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (24) :11867-11870
[7]   Synthesis of novel N-pyridylcantharidinimides by using high pressure [J].
Lin, PY ;
Shi, SJ ;
Lin, LH ;
Chen, HF ;
Hsu, FL .
JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 2001, 48 (01) :49-53
[8]   New cantharidinimides from cantharidin and 2-arylethylamines: Efficient synthesis under high pressure [J].
Lin, PY ;
Shi, SJ ;
Hsu, FL ;
Chen, CF .
JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 1998, 45 (02) :323-326
[9]  
Lin PY, 2000, BIOORG CHEM, V28, P266
[10]  
NEUMANN J, 1995, J PHARMACOL EXP THER, V274, P530